a chemical conjugate of pre-immune mouse IgG antibody
and the ribosome-inactivating protein, saporin
serves as a control for mouse IgG-containing immunolesioning agents
Mouse IgG-SAP serves as a control for the targeted toxins that
use a mouse monoclonal: 192-IgG-SAP, OX7-SAP, Anti-DBH-SAP, ME20.4-SAP, Anti-SERT-SAP, Anti-CD25-SAP human, Mac-1-SAP rat, Anti-CD22-SAP, Anti-6 His-ZAP, Anti-GFP-ZAP, Anti-Basigin2-SAP, Anti-V5-ZAP, and Anti-FLAG (M5)-ZAP.
This control molecule is the same molecular weight, consists of similar, comparable materials (saporin and a mouse IgG) and is synthesized with the same protocols as the targeted toxins. The difference is the cell-specific targeting agents are replaced with "blanks," antibodies or peptides that have no specificity, and no ability to target cells.
Check out these articles in Targeting Trends for more information:
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