a chemical conjugate of pre-immune mouse IgG antibody
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

This product serves as a control for the immunotoxins that use a mouse monoclonal: 192-IgG-SAP, OX7-SAP, Anti-DBH-SAP, ME20.4-SAP, Anti-SERT-SAP, Anti-CD25-SAP human, Anti-CD22-SAP, and Mac-1-SAP rat. It is the same molecular weight, consists of comparable materials (saporin and a mouse IgG) and is synthesized with the same protocol as the targeted immunotoxins. The difference is the cell-specific antibodies are replaced with "blanks," antibodies that have no specificity, and no ability to target cells.

Effective Tool

• The perfect control molecule for targeted immunotoxins
• There's no mixing of reagents; use it "as is" out of the vial
• No complicated calculations; use the same amount as the targeted toxin
• Ready to use: it comes sterile-filtered in phosphate-buffered saline
• It has the activity of non-targeted saporin, that is, almost none

Check out these articles in Targeting Trends for more information. Jul-Aug-Sept 2008 - Cover Article: Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress (read article) January 2002 - Control Conjugates: The Perfect Companion for Targeted Toxins, continued April 2001 - Targeting Tools: Controls for Immunotoxins