a chemical conjugate of pre-immune goat IgG antibody
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

This molecule is the perfect control for use with the "second" immunotoxins Mab-ZAP, Rab-ZAP, Hum-ZAP, Rat-ZAP, and Anti-M-ZAP. The secondary antibody conjugates are used with a primary antibody (a mouse monoclonal, rabbit polyclonal, human monoclonal, rat monoclonal, or IgM mouse monoclonal) to determine if the primary antibody can internalize saporin and would, therefore, be suitable for conjugation as a primary immunotoxin. Goat IgG-SAP, used in place of the secondary antibody conjugate, will give a definitive baseline for comparison of the activity of the primary antibody to internalize.

Effective Tool