a chemical conjugate of pre-immune goat IgG antibody
and the ribosome-inactivating protein, saporin
serves as a control for goat IgG-containing immunolesioning agents
Goat IgG-SAP is the perfect control for use with secondary conjugates Mab-ZAP, Rab-ZAP, Hum-ZAP, Rat-ZAP, Anti-M-ZAP, Hug-M-ZAP, Fab-ZAP mouse, Fab-ZAP human, Fab-ZAP rat, Fab-ZAP rabbit and gPIG-ZAP. The secondary antibody conjugates are used with a primary antibody (a mouse monoclonal, rabbit polyclonal, human monoclonal, rat monoclonal, or IgM mouse monoclonal) to determine if the primary antibody can internalize saporin and would, therefore, be suitable for conjugation as a primary immunotoxin. Goat IgG-SAP, used in place of the secondary antibody conjugate, will give a definitive baseline for comparison of the activity of the primary antibody to internalize.
- The perfect control molecule for secondary antibody conjugates
- There's no mixing of reagents; use it "as is" out of the vial
- No complicated calculations; use the same amount as the targeted toxin
- Ready to use: it comes sterile-filtered in phosphate-buffered saline
- It has the activity of non-targeted saporin, that is, almost none
Check out these articles in Targeting Trends for more information:
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