a chemical conjugate between a non-targeted peptide
and the ribosome-inactivating protein, saporin
serves as a control for peptide-targeted SAP conjugates
Blank-SAP is the perfect control for use with peptide conjugates such as: SSP-SAP, Dermorphin-SAP, CRF-SAP, NPY-SAP, CCK-SAP, Galanin-SAP, Bombesin-SAP, Oxytocin-SAP, Neurotensin-SAP and NK3-SAP. The sequence of the non-targeted peptide of this molecule is an 11-amino acid, randomly mixed version of the sequence of melanocyte-stimulating hormone, with amino acid residues that are typical of peptides that bind to G-protein-coupled receptors. Examination of the peptide sequence using NCBI/BLAST reveals no homologous sequences. Thus, Blank-SAP can be used as control for any non-specific effects of the toxin and provides a definitive baseline for determining the effects of a targeted peptide conjugate.
Check out these articles in Targeting Trends for more information:
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