a chemical conjugate between a non-targeted peptide
and the ribosome-inactivating protein, saporin

(molecular weight 32 kDa)

This molecule is the perfect control for use with peptide conjugates such as: SSP-SAP, Dermorphin-SAP, CRF-SAP, Orexin-SAP, NPY-SAP, CCK-SAP, and Galanin-SAP. The sequence of the non-targeted peptide of Blank-SAP is an 11-amino acid, randomly mixed version of the sequence of melanocyte-stimulating hormone, with amino acid residues that are typical of peptides that bind to G-protein-coupled receptors. Examination of the peptide sequence using NCBI/BLAST reveals no homologous sequences. Thus, Blank-SAP can be used as control for any non-specific effects of the toxin and provides a definitive baseline for determining the effects of a targeted peptide conjugate.

Effective Tool

• The perfect control molecule for peptide conjugates
• There's no mixing of reagents; use it "as is" out of the vial
• No complicated calculations; use the same amount as the targeted toxin
• Ready to use: it comes sterile-filtered in phosphate-buffered saline
• It has the activity of non-targeted saporin, that is, almost none

Check out this article in Targeting Trends for more information. Oct-Nov-Dec 2009 - Ablation of GRPR+ Neurons in the Spinal Cord by Bombesin-Saporin Knocks Out Itch Sensation in Mice Without Affecting Pain Circuit, continued January 2002 - Control Conjugates: The Perfect Companion for Targeted Toxins, continued