A fluorescent conjugate of the mouse monoclonal antibody 192-IgG and Alexa488. 192-IgG is the antibody to the p75 neurotrophin receptor (p75^NTR). The p75^NTR, also known as the low affinity NGF receptor (LNGFR) binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75^NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.

• Rat p75^NTR-bearing cells

Applications