Mab-ZAP

a chemical conjugate of affinity-purified goat anti-mouse IgG
and the ribosome-inactivating protein, saporin

Mab-ZAP uses your primary mouse monoclonal IgG antibody to target and eliminate cells that recognize your primary antibody. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-mouse IgG) to "piggyback" onto YOUR mouse primary antibody. Mab-ZAP can be utilized for screening mouse IgG antibodies for internalization and/or their suitability to make potent immunotoxins. When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.

Fab-ZAP mouse (Cat. #IT-48) is also available and uses a monovalent antibody conjugate to target your mouse monoclonal IgG.

Elimination of Specific Cell Type

• Cells that internalize your mouse monoclonal antibody will be eliminated.
• Potency may vary according to the specificity and affinity of YOUR antibody to ITS receptor.
• Second immunotoxins are most effective in determining specificity of your monoclonal antibody and suitability for conjugation as a primary immunotoxin.
• ATS recommends that you order a custom conjugation of your antibody to saporin when the in vitro results confirm the desired specificity.

Protocols: Preparing for a Cytotoxicity Assay; Preparing Test Samples

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Check out these articles in Targeting Trends for more information:

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