Rab-ZAP

a chemical conjugate of affinity-purified goat anti-rabbit IgG
and the ribosome-inactivating protein, saporin

Rab-ZAP uses your primary rabbit affinity-purified polyclonal IgG antibody to target and eliminate cells that recognize your primary antibody. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-rabbit IgG) to "piggyback" onto YOUR rabbit primary antibody. Rab-ZAP can be utilized for screening rabbit IgG antibodies for internalization and/or their suitability to make potent immunotoxins. When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.

Fab-ZAP rabbit (Cat. #IT-57) is also available and uses a monovalent antibody conjugate to target your rabbit polyclonal IgG.

Elimination of Specific Cell Type

• Cells that internalize your rabbit affinity-purified polyclonal antibody will be eliminated.
• Potency may vary according to the specificity and affinity of YOUR antibody to ITS receptor.
• Second immunotoxins are most effective in determining specificity of your polyclonal antibody and suitability for conjugation as a primary immunotoxin.
• ATS recommends that you order a custom conjugation of your antibody to saporin when the in vitro results confirm the desired specificity.

Protocols: Preparing for a Cytotoxicity Assay; Preparing Test Samples

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Check out these articles in Targeting Trends for more information:

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