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Goat-ZAP

a chemical conjugate of affinity-purified rabbit anti-goat IgG
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

Goat-ZAP uses your goat primary antibody to target and eliminate cells. Upon binding to a goat IgG that recognizes an extracellular domain of a cell surface antigen, Goat-ZAP will be taken inside the cell by antibody-mediated internalization. The entrance of saporin into the cell will result in protein synthesis inhibition and eventual cell death after 2-4 days. This reagent can be utilized for screening goat IgG antibodies for internalization and/or their suitability to make potent immunotoxins.

Elimination of Specific Cell Type

Protocols: Preparing for a Cytotoxicity Assay; Preparing Test Samples

news article

Check out these articles in Targeting Trends for more information.

Apr-May-Jun 2007 - Targeting Tools: New Product

Standard Pricing
IT-36-25 25 micrograms
$185
IT-36-100 100 micrograms
$675
IT-36-250 250 micrograms
$1595
Kit Pricing
includes Control Conjugate for control
KIT-36-25 25 micrograms
$290
KIT-36-100 100 micrograms
$1035
KIT-36-250 250 micrograms
$2400

References

Data Sheet

Summary

Control and Related Services: Rabbit IgG-SAP (Cat. #IT-35), Custom Services

 

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