a chemical conjugate of affinity-purified goat anti-human
IgM
and the ribosome-inactivating protein, saporin
Hug-M-ZAP uses your primary human monoclonal IgM antibody to target and eliminate cells that recognize your primary antibody. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-human IgM) to "piggyback" onto YOUR human primary antibody. Hug-M-ZAP can be utilized for screening human IgM antibodies for internalization and/or their suitability to make potent immunotoxins. When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.
Elimination of Specific Cell Type
- Cells that internalize your human monoclonal IgM antibody will be eliminated.
- Potency may vary according to the specificity and affinity of YOUR antibody to ITS receptor.
- Second immunotoxins are most effective in determining specificity of your monoclonal antibody and suitability for conjugation as a primary immunotoxin.
- ATS recommends that you order a custom conjugation of your antibody to saporin when the in vitro results confirm the desired specificity
Protocols: Preparing for a Cytotoxicity Assay; Preparing Test Samples
Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-43 Pricing in your currency. The kit includes the following controls: Goat IgG-SAP, Cat. #IT-19;
This product is available individually and as a kit (Cat. #KIT-43).
You may also be interested in these products for Hug-M-ZAP ^, Cat. #IT-43.
Controls: Goat IgG-SAP, Cat. #IT-19;
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