Intraventricular injection of 192-IgG-SAP (192-Saporin) results in almost complete elimination of LNGFR (p75NTR)-positive cells in rat. 192-IgG-SAP is directed to a cell-surface antigen that is only expressed at high levels on neurons in the cholinergic basal forebrain (CBF). The antigen, p75NTR, is not expressed on the neighboring, non-cholinergic neurons. This immunotoxin provides researchers with a powerful lesioning tool - more specific and effective than chemical, surgical or electrolytic lesioning.
To eliminate p75NTR-expressing cells in mouse, use mu p75-SAP. To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP.
Elimination of Specific Cell Type
- 192-IgG-SAP recognizes p75NTR-expressing cells in rat.
- 192-IgG-SAP specifically eliminates the following:
- Cholinergic neurons of the basal forebrain
- Medial septum
- Diagonal band of Broca
- Nucleus basalis of Meynert
- Purkinje neurons of the cerebellum
Effective Tool to Study Behavior
Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of the following:
- Behavior (cholinergic forebrain function)
- Neuronal loss (e.g. Alzheimer's disease)
- Plasticity of other systems in response to loss
- Replacement therapy
- Drug effects and dependence
Check out these articles in Targeting Trends for more information:Please select the button below for Cat. #IT-01 Pricing in your currency.
This product is available individually and as a kit. The kit includes the following controls: PR-01, IT-18
You may also be interested in these products for 192-IgG-SAP (192-Saporin) ^, Cat. #IT-01.
Controls: Saporin, Cat. #PR-01; Mouse IgG-SAP, Cat. #IT-18;
Related Products: ME20.4-SAP ^, Cat. #IT-15; mu p75-SAP ^, Cat. #IT-16; 192-IgG Mouse Monoclonal, Cy3-labeled, Cat. #FL-01; 192-IgG Mouse Monoclonal, Alexa488-labeled, Cat. #FL-03;
You have no items in your shopping cart
Home
| Tutorial | Catalog
| News | References
| Search | Contact
| Site Map
ADVANCED
TARGETING SYSTEMS