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192-IgG-SAP (192-Saporin)
Catalog #IT-01

a chemical conjugate of a mouse monoclonal antibody to rat p75NTR and the ribosome-inactivating protein, saporin
targets cells expressing rat p75NTR

Intraventricular injection of 192-IgG-SAP (192-Saporin) results in almost complete elimination of LNGFR (p75NTR)-positive cells in rat. 192-IgG-SAP is directed to a cell-surface antigen that is only expressed at high levels on neurons in the cholinergic basal forebrain (CBF). The antigen, p75NTR, is not expressed on the neighboring, non-cholinergic neurons. This immunotoxin provides researchers with a powerful lesioning tool - more specific and effective than chemical, surgical or electrolytic lesioning.

To eliminate p75NTR-expressing cells in mouse, use mu p75-SAP. To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP.

Elimination of Specific Cell Type

Effective Tool to Study Behavior

Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of the following:


news articleCheck out these articles in Targeting Trends for more information:

Please select the button below for Cat. #IT-01 Pricing in your currency.
This product is available individually and as a kit. The kit includes the following controls: PR-01, IT-18

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References     Data Sheet     

You may also be interested in these products for 192-IgG-SAP (192-Saporin) ^, Cat. #IT-01.
Controls: Saporin, Cat. #PR-01Mouse IgG-SAP, Cat. #IT-18
Related Products: ME20.4-SAP ^, Cat. #IT-15mu p75-SAP ^, Cat. #IT-16192-IgG Mouse Monoclonal, Cy3-labeled, Cat. #FL-01192-IgG Mouse Monoclonal, Alexa488-labeled, Cat. #FL-03

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