a chemical conjugate of the mouse monoclonal antibody OX7 (Cat. #AB-N08) and the ribosome-inactivating protein, saporin
targets cells expressing multi-species Thy-1.1
OX7, also known as Thy-1, Thy 1.1 or CD90, is expressed on a variety of cell types including thymocytes, neuronal cells, stem cells, T lymphocytes (mouse), immature B cells (rat) and connective tissues. It is involved in regulation of adhesion and signal transduction by T cells. It may contribute to inhibition of proliferation differentiation of hematopoietic stem cells and neuron memory formation in the CNS.
Administration of OX7-SAP results in elimination of Thy-1.1-positive cells in rat, mouse, rabbit, or guinea pig. Permanent and selective removal of Thy-1.1 positive cells makes an important animal model for the study of neurotransmitter receptors, neuroanatomy, neural response to injury, and inducible immune suppression. This makes OX7-SAP an excellent tool for specific targeting of neuronal projections through suicide transport.
Elimination of Specific Cell Type
OX7-SAP is directed to a cell-surface antigen that is widely expressed on cells and specifically eliminates the following:
- Neurons of PNS and CNS
- A subset of thymic-derived lymphocytes
- Cerebellar Purkinje neurons (intraventricular injection)
Effective Tool in Research Settings
Permanent and selective removal of Thy-1.1 positive cells makes an important animal model for the study of the following:
- Neurotransmitter receptors
- Neural response to injury
- Inducible immune suppression
Check out these articles in Targeting Trends for more information:
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