Administration of OX7-SAP results in elimination of Thy-1.1-positive cells in rat, mouse, rabbit, or guinea pig. Note: Antibody reactivity and working conditions may vary between species. This makes OX7-SAP an excellent tool for specific targeting of neuronal projections through suicide transport.

Elimination of Specific Cell Type

OX7-SAP is directed to a cell-surface antigen that is widely expressed on cells and specifically eliminates the following:

• Neurons of PNS and CNS
• A subset of thymic-derived lymphocytes
• Cerebellar Purkinje neurons (intraventricular injection)

Effective Tool in Research Settings

Permanent and selective removal of Thy-1.1 positive cells makes an important animal model for the study of the following:

• Neurotransmitter receptors
• Neuroanatomy
• Neural response to injury
• Inducible immune suppression

Check out these articles in Targeting Trends for more information. Apr-May-Jun 2006 - Targeted Toxins in Pain, continued April 2002- Targeting Tools: OX7-SAP