a chemical conjugate of the rat monoclonal antibody to CD11b (Cat. #AB-N05)
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

The antibody is from the well-characterized M1/70 clone, and has been created by immunization from mouse macrophages, but reacts well with the human epitope also. It does not recognize the rat form. The immunotoxin is extremely potent, with an ED50 of 5 pM for a mouse monocytic cell line, more than five orders of magnitude more toxic than non-targeted saporin.

To eliminate Mac-1-positive cells in rat, use Mac-1-SAP rat (Cat. #IT-33).

Elimination of Specific Cell Type

Effective Tool to Study Disease States