a chemical conjugate of the rat monoclonal antibody to CD11b (Cat. #AB-N05)
and the ribosome-inactivating protein, saporin
targets cells expressing mouse / human mac-1 (CD11b) receptor

The antibody is from the well-characterized M1/70 clone, and has been created by immunization from mouse macrophages, but reacts well with the human epitope also. It does not recognize the rat form. The immunotoxin is extremely potent, with an ED50 of 5 pM for a mouse monocytic cell line, more than five orders of magnitude more toxic than non-targeted saporin.

To eliminate Mac-1-positive cells in rat, use Mac-1-SAP rat (Cat. #IT-33).

Elimination of Specific Cell Type

• Mac-1-positive (CD11b-positive) cells in mouse and human are eliminated with this reagent.
• All other cells are left untouched.
• Excellent for removing contaminating macrophages from primary cultures.

Effective Tool to Study Disease States

• Elimination of macrophages is useful to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer's.