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IB4-SAP

a chemical conjugate of the B4 lectin [from Griffonia (Bandeiraea) simplicifolia]
and the ribosome-inactivating protein, saporin

(molecular weight 160 kDa)

IB4-SAP specifically eliminates the IB4-positive neurons, while sparing the peptidergic neurons. Upon binding to the a-D-Galactopyranoside group expressed on the cell surface, IB4-SAP becomes internalized and saporin inhibits protein synthesis, resulting in the elimination of the neurons. The cytotoxin is extremely potent, with an ED50 of 110 pM for a-D-Galactopyranoside-expressing cells in vitro.

Elimination of Specific Cell Type

Effective Tool to Study Disease States

news article

Check out these articles in Targeting Trends for more information.

Jan-Feb-Mar 2005 - IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers, continued

Oct-Nov-Dec 2004 - Effects of IB4-SAP on Bladder Overactivity, continued

Apr-May-Jun 2003 - Biotinylated targeting: A viable option?, continued

January 2001 - Targeting Tools: IB4-SAP
Standard Pricing
IT-10-25 25 micrograms
$330
IT-10-100 100 micrograms
$1205
IT-10-250 250 micrograms
$2840
Kit Pricing
includes Saporin control
KIT-10-25 25 micrograms
$365
KIT-10-100 100 micrograms
$1340
KIT-10-250 250 micrograms
$3160

References

Data Sheet

Summary

Controls: Saporin (Cat. #PR-01)

Related Product: IB4 (Cat. #PR-02)

 

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