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Dermorphin-SAP / MOR-SAP

a chemical conjugate of dermorphin and the ribosome-inactivating protein, saporin
target: mu-opioid receptor (MOR)

(molecular weight 32 kDa)

Dermorphin-SAP (MOR-SAP) targets and eliminates cells expressing the mu opioid receptor (MOR). MOR-expressing neurons have long been considered some of the most important cells in the nervous systems because of their participation in pain, pain control, addiction, gastrointestinal motility, and mast cell function, among others. This specific cytotoxin provides new methods for understanding these neurons and how they work.

Elimination of Specific Cell Type

Effective Tool to Study Behavior

Permanent and selective removal of MOR-expressing neurons makes an important animal model for the study of the following:

news article

Check out these articles in Targeting Trends for more information.

Apr-May-Jun 2007 - Targeting Talk: Agonist Effects

Apr-May-Jun 2006 - Targeted Toxins in Pain, continued

Jan-Feb-Mar 2003 - Targeting Tools: Dermorphin-SAP

July 2001 - Dermorphin-SAP Kills MOR-Positive Cells, continued
Standard Pricing
IT-12-25 25 micrograms
$365
IT-12-100 100 micrograms
$1330
IT-12-250 250 micrograms
$3140
Kit Pricing
includes Saporin and Control Conjugate for control
KIT-12-25 25 micrograms
$505
KIT-12-100 100 micrograms
$1825
KIT-12-250 250 micrograms
$4265

References

Data Sheet

Summary

Controls: Saporin (Cat. #PR-01), Blank-SAP (Cat. #IT-21)

 

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