a chemical conjugate of dermorphin and the ribosome-inactivating protein, saporin
targets cells expressing mu-opioid receptor (MOR)
Dermorphin-SAP (MOR-SAP) targets and eliminates cells expressing the mu opioid receptor (MOR). MOR-expressing neurons have long been considered some of the most important cells in the nervous systems because of their participation in pain, pain control, addiction, gastrointestinal motility, and mast cell function, among others. This specific cytotoxin provides new methods for understanding these neurons and how they work. MOR-SAP is not suitable for retrograde transport.
Elimination of Specific Cell Type
Effective Tool to Study Behavior
Permanent and selective removal of MOR-expressing neurons makes an important animal model for the study of the following:
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