CRF-SAP

CRF-SAP

a chemical conjugate of human/rat CRF to the ribosome-inactivating protein, saporin

(molecular weight 35 kDa)

Corticotropin-releasing hormone/factor (CRH/CRF) is the principal neuropeptide involved in regulating the stress response. It stimulates ACTH release from the pituitary gland. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients.

Elimination of Specific Cell Type

Cells expressing the corticotropin-releasing factor (hormone) receptor 1 (CRF₁ receptor) are eliminated with this reagent.
All other cells are left untouched.
Not suitable for retrograde transport.

Effective Tool to Study Disease States

Elimination of CRF receptor-positive cells is useful to determine their neurobiological role(s).

Standard Pricing
IT-13-25	25 micrograms	$330
IT-13-100	100 micrograms	$1205
IT-13-250	250 micrograms	$2840
Kit Pricing includes Saporin and Control Conjugate for control
KIT-13-25	25 micrograms	$470
KIT-13-100	100 micrograms	$1700
KIT-13-250	250 micrograms	$3965

Controls: Saporin (Cat. #PR-01), Blank-SAP (Cat. #IT-21)