ME20.4-SAP

ME20.4-SAP

a chemical conjugate of the p75^NTR monoclonal antibody (Cat. #AB-N07)
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

This immunotoxin provides researchers with a powerful lesioning tool — more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species. Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75^NTR)-positive cells in rabbit. Tissue-directed injection in primates causes loss of p75^NTR-positive neurons. It is useful in immunostaining, immunoprecipitation, and inhibits the binding of NGF to p75^NTR.

Elimination of Specific Cell Type

The antibody recognizes p75^NTR in rabbit, sheep, dog, cat, raccoon, pig and several primate species.

ME20.4-SAP specifically eliminates cholinergic neurons of the basal forebrain and its projections to the cerebral cortex and hippocampus.

Effective Tool to Study Behavior

Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of the following:

Behavior (cholinergic forebrain function)

Neuronal loss (e.g. Alzheimer's disease)

Plasticity of other systems in response to loss

Drug effects and dependence

Standard Pricing

Kit Pricing
includes Saporin, Antibody, and Control Conjugate
for control

a chemical conjugate of the p75NTR monoclonal antibody (Cat. #AB-N07) and the ribosome-inactivating protein, saporin

a chemical conjugate of the p75^NTR monoclonal antibody (Cat. #AB-N07)
and the ribosome-inactivating protein, saporin