ME20.4-SAP (IT15)

a chemical conjugate of the p75^NTR monoclonal antibody (Cat. #AB-N07)
and the ribosome-inactivating protein, saporin

targets cells expressing mammalian p75^NTR

ME20.4-SAP provides researchers with a powerful lesioning tool — more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species, including rabbit and primate. Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75^NTR)-positive cells in rabbit. Tissue-directed injection in primates causes loss of p75^NTR-positive neurons. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer's disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

To eliminate p75^NTR-expressing cells in mouse, use mu p75-SAP (Cat. #IT-16). To eliminate p75^NTR-expressing cells in rat, use 192-IgG-SAP (Cat.#IT-01).

Elimination of Specific Cell Type

The antibody recognizes p75^NTR in rabbit, sheep, dog, cat, raccoon, pig and several primate species.
ME20.4-SAP specifically eliminates cholinergic neurons of the basal forebrain and its projections to the cerebral cortex and hippocampus.

Effective Tool to Study Behavior

Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of the following:

Behavior (cholinergic forebrain function)
Neuronal loss (e.g. Alzheimer's disease)
Plasticity of other systems in response to loss
Replacement therapy
Drug effects and dependence

news article Check out these articles in Targeting Trends for more information:

Please select the button below for Cat. #IT-15 Pricing in your currency.
This product is available individually and as a kit (Cat. #KIT-15).

The kit includes the following controls: Saporin, Cat. #PR-01; NGFr (ME20.4, p75) Mouse Monoclonal, Cat. #AB-N07; Mouse IgG-SAP, Cat. #IT-18;

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Controls: Saporin, Cat. #PR-01; NGFr (ME20.4, p75) Mouse Monoclonal, Cat. #AB-N07; Mouse IgG-SAP, Cat. #IT-18;

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