a chemical conjugate of the p75NTR monoclonal
antibody (Cat. #AB-N07)
and the ribosome-inactivating protein, saporin
targets cells expressing mammalian p75NTR
ME20.4-SAP provides researchers with a powerful lesioning tool — more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species, including rabbit and primate. Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75NTR)-positive cells in rabbit. Tissue-directed injection in primates causes loss of p75NTR-positive neurons. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer's disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.
Elimination of Specific Cell Type
Effective Tool to Study Behavior
Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of the following:
- Behavior (cholinergic forebrain function)
- Neuronal loss (e.g. Alzheimer's disease)
- Plasticity of other systems in response to loss
- Replacement therapy
- Drug effects and dependence
Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-15 Pricing in your currency.
This product is available individually and as a kit (Cat. #KIT-15).
You may also be interested in these products for ME20.4-SAP, Cat. #IT-15.
You have no items in your shopping cart