a chemical conjugate of the affinity-purified rabbit polyclonal
antibody p75NTR (Cat. #AB-N01AP)
and the ribosome-inactivating protein, saporin
targets cells expressing mouse p75NTR
Conjugation of a low affinity nerve growth factor receptor (p75NTR) antibody to saporin has produced a cytotoxin that eliminates the CBF neurons, while sparing neighboring neurons that express GAD, calbindin and parvalbumin. mu p75-SAP eliminates cells expressing p75NTR in rat. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer's disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence. To eliminate p75NTR-expressing cells in rat, use 192-IgG-SAP (Cat. #IT-01). To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP (Cat. #IT-15). Elimination of Specific Cell Type
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Effective Tool to Study Behavior
Permanent and selective removal of cholinergic forebrain neurons makes an important animal model and can be used in conjunction with knockout models for the study of the following:
- Behavior (cholinergic forebrain function)
- Neuronal loss (e.g. Alzheimer’s disease)
- Plasticity of other systems in response to loss
- Replacement therapy
- Drug effects and dependence
Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-16 Pricing in your currency. The kit includes the following controls: Saporin, Cat. #PR-01; NGFr (mu p75) Rabbit Polyclonal, affinity-purified * +, Cat. #AB-N01AP; Rabbit IgG-SAP, Cat. #IT-35;
This product is available individually and as a kit (Cat. #KIT-16).
You may also be interested in these products for mu p75-SAP ^, Cat. #IT-16.
Controls: Saporin, Cat. #PR-01; NGFr (mu p75) Rabbit Polyclonal, affinity-purified * +, Cat. #AB-N01AP; Rabbit IgG-SAP, Cat. #IT-35;
Related Products: 192-IgG-SAP (192-Saporin) ^, Cat. #IT-01; ME20.4-SAP ^, Cat. #IT-15;
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