a chemical conjugate of a monoclonal antibody to human CD25 (Tac,
IL-2 receptor, Cat #AB-18)
and the ribosome-inactivating protein, saporin
targets cells expressing human CD25
The CD25 monoclonal antibody inhibits the proliferation of interleukin-2 (IL-2)-dependent human continuous T-cell lines. It blocks the human T-cell receptor for IL-2 by binding to the alpha-chain of the IL-2 receptor. Anti-CD25-SAP recognizes and specifically eliminates cells expressing human CD25. Anti-CD25 immunotoxins have been shown to remove activated T lymphocytes in culture, and can be used to understand the role of this population in its various processes in the immune system. It has also been suggested for clinical use in the treatment of T-cell leukemias and lymphomas.
To eliminate CD25-expressing cells in mouse, use Anti-CD25-SAP mouse (Cat. #IT-29).
Elimination of Specific Cell Type
- Specifically targets rat cells that express the human interleukin-2 (IL-2) receptor.
- All other cells are left untouched.
Effective Tool
- Anti-CD25 immunotoxins have been shown to remove activated T lymphocytes in culture, and can be used to understand the role of this population in its various processes in the immune system.
Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-24 Pricing in your currency. The kit includes the following controls: Saporin, Cat. #PR-01; CD25 Mouse Monoclonal * +, Cat. #AB-18; Mouse IgG-SAP, Cat. #IT-18;
This product is available individually and as a kit (Cat. #KIT-24).
You may also be interested in these products for Anti-CD25-SAP human ^, Cat. #IT-24.
Controls: Saporin, Cat. #PR-01; CD25 Mouse Monoclonal * +, Cat. #AB-18; Mouse IgG-SAP, Cat. #IT-18;
Related Products: Anti-CD25-SAP mouse ^, Cat. #IT-29; CD25 Rat Monoclonal * +, Cat. #AB-19;
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