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Anti-DAT-SAP

a chemical conjugate of a rat monoclonal antibody to the second extracellular loop of the dopamine transporter
(DAT-ECD, Cat. #AB-N17) and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

The dopamine transporter (DAT) is a sodium-dependent reuptake carrier that is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's syndrome, schizophrenia, and addiction. It is a 12-transmembrane domain transporter with the N- and C- terminus regions located within the cytoplasm. Because of its importance in dopamine use, DAT is an identifier of dopaminergic neurons.

Elimination of Specific Cell Type

Effective Tool

news article

Check out these articles in Targeting Trends for more information.

July 2003 - A New Immunotoxin for Targeting Dopaminergic Neurons

July 2003 - Featured Product: Targeting the Dopamine Transporter
Standard Pricing
IT-25-25 25 micrograms
$200
IT-25-100 100 micrograms
$730
IT-25-250 250 micrograms
$1720
Kit Pricing
includes Saporin, Antibody, and Control Conjugate
for control
KIT-25-25 25 micrograms
$400
KIT-25-100 100 micrograms
$1450
KIT-25-250 250 micrograms
$3375

References

Data Sheet

Summary

Controls: Saporin (Cat. #PR-01), Rat IgG-SAP (Cat. #IT-17), Anti-DAT-ECD (Cat. #AB-N17), Anti-DAT-NT (Cat. #AB-N18)

 

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