a chemical conjugate of a rat monoclonal antibody to the second extracellular loop of the dopamine transporter
(DAT-ECD, Cat. #AB-N17) and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

The dopamine transporter (DAT) is a sodium-dependent reuptake carrier that is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's syndrome, schizophrenia, and addiction. It is a 12-transmembrane domain transporter with the N- and C- terminus regions located within the cytoplasm. Because of its importance in dopamine use, DAT is an identifier of dopaminergic neurons.

Elimination of Specific Cell Type

• Recognizes cells that express DAT in rat and human.
• All other cells are left untouched.

Effective Tool

• Specific elimination of cells that express DAT is useful in studying the role of dopaminergic neurons in one of the devastating diseases of old age, Parkinson’s.

Check out these articles in Targeting Trends for more information. July 2003 - A New Immunotoxin for Targeting Dopaminergic Neurons July 2003 - Featured Product: Targeting the Dopamine Transporter