a chemical conjugate of a rat monoclonal antibody to the second extracellular loop of the dopamine transporter (DAT-ECD, Cat. #AB-N17) and the ribosome-inactivating protein, saporin
targets cells expressing rat / human dopamine transporter (DAT)
The dopamine transporter (DAT) is a sodium-dependent reuptake carrier that is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's syndrome, schizophrenia, and addiction. It is a 12-transmembrane domain transporter with the N- and C-terminus regions located within the cytoplasm. Because of its importance in dopamine use, DAT is an identifier of dopaminergic neurons. Anti-DAT-SAP is highly specific for cells that express DAT, including mesencephalic dopamine neurons of the substantia nigra, pars compacta, and ventral tegmental area. Specific elimination of cells that express DAT is useful in studying the role of dopaminergic neurons in one of the devastating diseases of old age, Parkinson's. |
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Elimination of Specific Cell Type
- Recognizes cells that express DAT in rat and human.
- All other cells are left untouched.
Effective Tool
- Specific elimination of cells that express DAT is useful in studying the role of dopaminergic neurons in one of the devastating diseases of old age, Parkinson’s.
Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-25 Pricing in your currency. The kit includes the following controls: Saporin, Cat. #PR-01; Dopamine Transporter Rat Monoclonal (DAT-ECD), Cat. #AB-N17; Rat IgG-SAP, Cat. #IT-17;
This product is available individually and as a kit (Cat. #KIT-25).
You may also be interested in these products for Anti-DAT-SAP, Cat. #IT-25.
Controls: Saporin, Cat. #PR-01; Dopamine Transporter Rat Monoclonal (DAT-ECD), Cat. #AB-N17; Rat IgG-SAP, Cat. #IT-17;
Related Products: Dopamine Transporter Rat Monoclonal (DAT-NT), Cat. #AB-N18;
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