NPY-SAP

NPY-SAP

a chemical conjugate of neuropeptide Y and the ribosome-inactivating protein, saporin

(molecular weight 34 kDa)

Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Neuropeptide Y family of peptides signal through a family of G protein-coupled receptors present in the brain and sympathetic neurons. These NPY receptors recognize NPY and related peptides.

Elimination of Specific Cell Type

Specifically eliminates cells expressing the NPY receptor.
All other cells are left untouched.
Not suitable for retrograde transport.

Check out this article in Targeting Trends for more information.

Oct-Nov-Dec 2006 - Basomedial Hypothalamic Injections of Neuropeptide Y Conjugated to Saporin Selectively Disrupt Hypothalamic Controls of Food Intake, continued

Oct-Nov-Dec 2004 - Featured Product: NPY-SAP

Standard Pricing
IT-28-25	25 micrograms	$200
IT-28-100	100 micrograms	$730
IT-28-250	250 micrograms	$1720
Kit Pricing includes Saporin and Control Conjugate for control
KIT-28-25	25 micrograms	$340
KIT-28-100	100 micrograms	$1225
KIT-28-250	250 micrograms	$2845

Controls: Saporin (Cat. #PR-01), Blank-SAP (Cat. #IT-21)