a chemical conjugate of an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence
and the ribosome-inactivating protein, saporin
targets cells expressing rat GABA-1 transporter (GAT-1)

GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, sleep disorders, neuropathic pain, and attention deficit disorders.

Elimination of Specific Cell Type

• GAT1-SAP specifically eliminates cells expressing GAT-1, the GABA transporter.
• All other cells are left untouched.