a chemical conjugate of an affinity-purified rabbit polyclonal antibody against a GAT-1 peptide sequence and the ribosome-inactivating protein, saporin
targets cells expressing rat GABA-1 transporter (GAT-1)
GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving γ-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, sleep disorders, neuropathic pain, and attention deficit disorders. GAT1-SAP recognizes cells that express the GABA-1 transporter, GAT-1 in rat. The peptide used as an antigen has 100% sequence homology between rat, human, mouse, and bovine GAT-1. Elimination of Specific Cell Type
Effective Tool
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Check out these articles in Targeting Trends for more information:
Please select the button below for Cat. #IT-32 Pricing in your currency. The kit includes the following controls: Saporin, Cat. #PR-01; GAT-1 Rabbit Polyclonal, affinity-purified *, Cat. #AB-N37; Rabbit IgG-SAP, Cat. #IT-35;
This product is available individually and as a kit (Cat. #KIT-32).
You may also be interested in these products for GAT1-SAP ^, Cat. #IT-32.
Controls: Saporin, Cat. #PR-01; GAT-1 Rabbit Polyclonal, affinity-purified *, Cat. #AB-N37; Rabbit IgG-SAP, Cat. #IT-35;
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