chemical conjugate of mouse monoclonal antibody to CD11b (Cat. #AB-N06)
and the ribosome-inactivating protein, saporin

(molecular weight 210 kDa)

This immunotoxin recognizes the rat Mac-1 (CD11b) receptor. The antibody was developed in mice immunized with rat neutrophils. It does not cross-react with the human or mouse epitope. The immunotoxin is extremely potent, three orders of magnitude more effective than non-targeted saporin and an ED50 of 6 pm in rat macrophages in vitro.

To eliminate Mac-1-positive cells in mouse/human, use Mac-1-SAP mouse/human (Cat. #IT-06).