a chemical conjugate of mouse monoclonal antibody to CD11b (Cat. #AB-N06)
and the ribosome-inactivating protein, saporin
targets cells expressing rat mac-1 (CD11b) receptor

This immunotoxin recognizes the rat Mac-1 (CD11b) receptor. The antibody was developed in mice immunized with rat neutrophils. It does not cross-react with the human or mouse epitope. The immunotoxin is extremely potent, three orders of magnitude more effective than non-targeted saporin and an ED50 of 6 pm in rat macrophages in vitro.

To eliminate Mac-1-positive cells in mouse/human, use Mac-1-SAP mouse/human (Cat. #IT-06).

Elimination of Specific Cell Type

• Mac-1-positive (CD11b positive) cells in rat are eliminated with this reagent.
• All other cells are left untouched.
• Excellent for removing contaminating macrophages from primary cultures.

Effective Tool to Study Disease States

• >Elimination of macrophages is useful to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer's