a chemical conjugate of rat galanin and the ribosome-inactivating protein, saporin
targets cells expressing galanin-1 receptor
Galanin is a 29-amino acid peptide (30 amino acids in humans) implicated in a variety of functions including nociception, appetite, learning, and memory. It is widely distributed throughout the neural and endocrine systems, playing roles in the secretion of insulin, somatostatin, glucagon, dopamine, and growth hormone, and inhibiting the release of acetylcholine and substance P from myenteric neurons. Galanin-SAP eliminates cells expressing the galanin-1 receptor. It is not suitable for retrograde transport.
Elimination of Specific Cell Type
- Cells expressing the galanin-1 receptor are eliminated.
- All other cells are left untouched.
- Not suitable for retrograde transport.
- Elimination of cells expressing the galanin-1 receptor is useful to study their role in a variety of functions including nociception, appetite, learning, and memory.
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