a chemical conjugate of recombinant mouse leptin and the ribosome-inactivating protein, saporin
targets cells expressing leptin receptor

Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (α-MSH), and thereby is a very influential mediator of satiety. This new product could be used to eliminate leptin receptor-expressing cells as an excellent complement to NPY-SAP (IT-28) and Oxytocin-SAP (IT-46) in studying satiety, appetite, and metabolism.

Elimination of Specific Cell Type

• Cells expressing the leptin-receptor are eliminated with this reagent
• All other cells are left untouched.