a chemical conjugate of neurotensin and the ribosome-inactivating protein, saporin
targets cells expressing neurotensin receptors

Neurotensin is a 13 amino acid peptide, released by the hypothalamus and synthesized as part of a larger precursor protein that also includes the related neuropeptide neuromedin N. Implicated in the regulation of leutinizing hormone and prolactin release, neurotensin also has a significant interaction with the dopaminergic system. Intrathecal neurotensin has also been shown to be anti-nociceptive.

Elimination of Specific Cell Type

• Cells that express neurotensin receptors are eliminated with this reagent
• All other cells are left untouched.