a chemical conjugate of neurotensin and the ribosome-inactivating protein, saporin
targets cells expressing neurotensin receptors
Neurotensin is a 13-amino-acid peptide found in the brain and spinal cord (first characterized by Carraway and Leeman). It is released by the hypothalamus and synthesized as part of a larger precursor protein that also includes the related neuropeptide neuromedin N. Neurotensin affects pituitary hormone release, interacts with the dopaminergic system, and is involved in vasodilation and hypotension. It can also modulate pain perception. Intrathecal neurotensin has also been shown to be anti-nociceptive. Neurotensin-SAP will specifically eliminate cells that express neurotensin receptors.
Elimination of Specific Cell Type
- Cells that express neurotensin receptors are eliminated with this reagent
- All other cells are left untouched.
To STIMULATE cells expressing neurotensin receptors, use Neurotensin-CTA (Cat. #IT-60)
- Elimination of cells expressing neurotensin receptors is useful in studying how they affect pituitary hormone release, interact with the dopaminergic system, and are involved in vasodilation, hypotension and pain perception.
Check out these articles in Targeting Trends for more information:
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