NK3-SAP

a chemical conjugate of an analog of the neurokinin B peptide ([MePhe7]-NKB) and the ribosome-inactivating protein, saporin

targets cells expressing the NK3 receptor

An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NK3-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several locations, KNDy neurons reside only within the hypothalamic arcuate nucleus of many mammalian species and are critical for reproductive function. NK3-SAP can also be used to target and selectively destroy NK3r-expressing cells in other regions of the brain.

Elimination of Specific Cell Type Cells that express the neurokinin 3 receptor are eliminated with this reagent All other cells are left untouched. Effective Tool Elimination of NK3 receptor-expressing cells is useful in studying their role in reproductive function.

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Check out these articles in Targeting Trends for more information:

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