CBF Lesioning in Rabbits, contributed by Dr. Thomas Beach - continued on page 6

Product information related to cover article: ME20.4-SAP, Cat. #IT-15

Chronic Pain Therapeutic (article) - continued on page 2

NIDA funds ATS research on Galanin

Chronic Pain Therapeutic (article) - continued from page 1

• Impaired acquisition of a Morris water maze task following selective destruction of cerebellar Purkinje cells with OX7-saporin. (2000) Gandhi CC, Kelly RM, Wiley RG, Walsh TJ. Behav Brain Res 109(1):37-47. (OX7-SAP, Cat. #IT-02)
• Ectopic noradrenergic hyperinnervation does not functionally compensate for neonatal forebrain acetylcholine lesion. (2000) Pappas BA, Nguyen T, Brownlee B, Tanasoiu D, Fortin T, Sherren N. Brain Res 867(1-2):90-99. (192-IgG-SAP, Cat. #IT-01)
• NGF-mediated alteration of NF-kB binding activity after partial immunolesions to rat cholinergic basal forebrain neurons. (2000) Gu Z, Toliver-Kinsky T, Glasgow J, Werrbach-Perez K, Perez-Polo JR. Intl J Dev Neurosci 18(4-5):455-468. (192-IgG-SAP, Cat. #IT-01)
• Preferential destruction of cerebellar Purkinje cells by OX7-saporin. (2000) Angner RT, Kelly RM, Wiley RG, Walsh TJ, Reuhl KR. Neurotoxicology 21(3):395-403. (OX7-SAP, Cat. #IT-02)
• Sustained visual attention performance-associated prefrontal neuronal activity: evidence for cholinergic modulation. (2000) Gill TM, Sarter M, Givens B. J Neurosci 20(12):4745-4757. (192-IgG-SAP, Cat. #IT-01)
• Immunolocalization of the cocaine- and antidepressant-sensitive 1-norepinephrine transporter. (2000) Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. J Comp Neurol 420(2):211-232. (Anti-DBH-SAP, Cat. #IT-03)

• Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rat. (2000) Ferencz I, Leanza G, Nasnobashvili A, Kokaia M, Lindvall O. Eur J Neurosci 12(6):2107-2116. (192-IgG-SAP, Cat. #IT-01)
• Repeated immunolesions display diminished stress response signal. (2000) Gu Z, Yu J, Werrbach-Perez K, Perez-Polo JR. Int J Dev Neurosci 18(2-3):177-183. (192-IgG-SAP, Cat. #IT-01)
• Cholinergic excitation of septohippocampal GABA but not cholinergic neurons: implications for learning and memory. (2000) Wu M, Shanabrough M, Leranth C, Alreja M. J Neurosci 20(10):3900-3908. (Cy3-labeled 192-IgG, Cat. #FL-01)
• Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs. (2000) Stowell JR, Berntson GG, Sarter M. Psychopharmacol 150(2):141-149. (192-IgG-SAP, Cat. #IT-01)
• Intracerebroventricular infusion of CHO5, a rat monoclonal antibody directed against mouse low-affinity nerve growth factor receptor (p75NTR), specifically labels basal forebrain cholinergic neurons in mouse brain. (2000) Rossner, S, Schliebs, R, Bigl, V. Metab Brain Dis 15(1):17-27. (Antibody to Nerve Growth Factor (p75) Receptor, Cat. #AB-N02)

• What is a second immunotoxin (secondary conjugate)?
• How does a second immunotoxin target?
• What happens when the second immunotoxin gets inside the cell?
• Are there different types of second immunotoxins available?
• What is the ration of antibody to second immunotoxin for in vitro testing?

CBF Lesioning in Rabbits  - continued from page 1

Targeting Ticklers (Jokes)

• Mouse-Specific p75 Immunotoxin (Cat. #IT-16)
• ME20.4 Monoclonal (Cat. #AB-N07) and ME20.4 Immunotoxin (Cat. #IT-15)
• Neurotransmitter Antibodies

Targeting Teaser (Jumble)