Immunolesioning: From Spinal Cord to Brain, contributed by Dr. Ann Schreihofer - continued on page 6

Product information related to cover article: Anti-DBH-SAP, Cat. #IT-03

ATS Joins Forces with Cytometry Research - continued on page 2

ATS Joins Forces with Cytometry Research - continued from page 1

Jennifer Martin wins "ATS Abstract of the Year" Award (abstract)

• Loss of nerve: a molecular approach to better treatment of chronic pain. (2000) Friedrich MJ. JAMA 283(2):187-188. (SP-SAP, Cat. #IT-07)
• Mab-ZAP: A tool for evaluating antibody efficacy for use in an immunotoxin. (2000) Kohls MD, Lappi DA. Biotechniques 28(1):162-165. (Mab-ZAP, Cat. #IT-04)
• Selective impairment of corticotropin-releasing factor 1 (CRF1) receptor-mediated function using CRF coupled to saporin. (2000) Maciejewski-Lenoir D, Heinrichs SC, Liu XJ, Ling N, Tucker A, Xie Q, Lappi DA, Grigoriadis DE. Endocrinology 141(2):498-504. (CRF-SAP, Cat. #IT-13)
• Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species. (2000) Tremere LA, Pinaud R, Grosche J, Hartig W, Rasmusson DD. NeuroReport 11(10):2177-2183. (Antibody to Nerve Growth Factor [p75] Receptor ME20.4 IgG, Cat. #AB-N07)
• Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG-saporin and 5,7-dihydroxytryptamine: neurochemical and behavioural characterization. (2000) Lehmann O, Jeltsch H, Lehnhardt O, Pain L, Lazarus C, Cassel JC. Eur J Neurosci 12(1):67-79. (192-IgG-SAP, Cat. #IT-01)

• Effects of cholinergic depletion on neural activity in different laminae of the rat barrel cortex. (2000) Herron P, Schweitzer JB. Brain Res 872(1-2):71-76. (192-IgG-SAP, Cat. #IT-01)
• Sustained effect of metrifonate on cerebral glucose metabolism after immunolesion of basal forebrain cholinergic neurons in rats. (2000) Bassant MH, Poindessous-Jazat F, Schmidt BH. Eur J Pharmacol 387(2):151-162. (192-IgG-SAP, Cat. #IT-01)
• Development of a method for intraparenchymal infusions of 192 IgG-saporin: a comment on Pizzo et al. (1999) Sarter M, Bruno JP, Miner LH, McGaughy J. J Neurosci Meth 96(2):169-170. (192-IgG-SAP, Cat. #IT-01)
• Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors. (2000) Winkler J, Ramirez GA, Thal LJ, Waite JJ. J Neurosci 20(2):834-844. (192-IgG-SAP, Cat. #IT-01)
• Preserved olfactory short-term memory after combined cholinergic and serotonergic lesions using 192 IgG-saporin and 5,7-dihydroxytryptamine in rats. (2000) Wirth S, Lehmann O, Bertrand F, Lazarus C, Jeltsch H, Cassel JC. NeuroReport 11:347-350. (192-IgG-SAP, Cat. #IT-01)
• In Vivo [¹²⁵I]-Iodobenzovesamicol binding reflects cortical cholinergic deficiency induced by specific immunolesion of rat basal forebrain cholinergic system. (2000) Sorger D, Schliebs R, Kampfer I, Rossner S, Heinicke J, Dannenberg C, Georgi P. Nucl Med Bio 27:23-31. (192-IgG-SAP, Cat. #IT-01)
• The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins. (2000) McGaughy J, Everitt BJ, Robbins TW, Sarter M. Behav Brain Res 115(2):251-263. (192-IgG-SAP, Cat. #IT-01 and ME20.4-SAP, Cat. #IT-15)
• Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat. (2000) Taylor BK, Roderick RE, Basbaum AI. Neurosci Lett 291:139-142. (192-IgG-SAP, Cat. #IT-01)
• Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. (2000) Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL. Brain Res 878:223-227. (Anti-DBH-SAP, Cat. #IT-03)
• Pain control: breaking the circuit. (2000) Hunt SP. Trends Pharmacol Sci 21(8):284-287. (SP-SAP, Cat. #IT-07)

•   Can you use targeted toxins in vivo?
•   How do you recommend administration of the targeted toxin?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

• IB4-SAP, Cat. #IT-10
• Featured Neuroscience Antibodies:
  Nerve Growth Factor (p75) receptor, Cat. #AB-N01, Cat. #AB-N02, and Cat. #AB-N07

Targeting Teaser (Jumble)