Safety Studies Begin for Chronic Pain Therapeutic (article) - continued on page 6

San Diego Biotechnology Center Opens

Featured Neuroscience Antibodies:
Mac-1 (Cat. #AB-N05 and Cat. #AB-N06) and trkA (Cat. #AB-N03)

• Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. (2000) Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M. Eur J Neurosci 12:4233-4242. (192-IgG-SAP, Cat. #IT-01)
• Baroreceptor sensitivity of rat supraoptic vasopressin neurons involves noncholinergic neurons in the DBB. (2000) Grindstaff RJ, Grindstaff RR, Cunningham JT. Am J Physiol Regul Integrative Comp Physiol 279:R1934-R1943. (192-IgG-SAP, Cat. #IT-01)
• Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: Forebrain cholinergic mechanisms. (2000) Lamprea MR, Cardenas FP, Silveira R, Morato S, Walsh TJ. Behav Brain Res 117:97-105. (192-IgG-SAP, Cat. #IT-01)
• Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function. (2000) Bannerman P, Nichols W, Puhalla S, Oliver T, Berman M, Pleasure D. J Neurosci Res 61:605-615. (Antibody to Nerve Growth Factor [p75] Receptor, Cat. #AB-N01)
• The molecular dynamics of pain control. (2000) Hunt SP, Mantyh PW. Nature Rev/Neurosci 2:83-91. (SP-SAP, Cat. #IT-07 and SSP-SAP, Cat. #IT-11)

• Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of C1 cells in rat. (2000) Schreihofer AM, Stornetta RL, Guyenet PG. J Physiol 529(1):221-236. (Anti-DBH-SAP, Ct. #IT-03)
• Neuronal lesioning with axonally transported toxins. (2000) Wiley RG and Kline IV RH. J Neurosci Meth 103:73-82. (SP-SAP, Cat. #IT-07 and 192-Saporin, Cat. #IT-01 and OX7-SAP, Cat. #IT-02)
• Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain. (2000) Villa AEP, Tetko IV, Dutoit P, Vantini G. BioSystems 58:219-228. (192-IgG-SAP, Cat. #IT-01)
• Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of a_2B adrenoceptors. (2000) Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M. J Neurosci 20(24):9242-9251. (Anti-DBH-SAP, Ct. #IT-03)
• Cortical cholinergic inputs mediate processing capacity: Effects of 192 IgG-saporin-induced lesions on olfactory span performance. (2000) Turchi J and Sarter M. Eur J Neurosci 12:4505-4514. (192-IgG-SAP, Cat. #IT-01)

• What is immunolesioning?
• What is suicide transport?
• How do I administer a targeted toxin to achieve suicide transport?

Safety Studies Begin for Chronic Pain Therapeutic (article) - continued from page 1

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

• Controls for Immunotoxins:
  Mouse IgG-SAP, Cat. #IT-18 and Rat IgG-SAP, Cat. #IT-17

Targeting Teaser (Jumble)