Immunolesioning Hippocampal Inhibitory Interneurons- continued on page 6

Product information related to cover article: SSP-SAP (Cat. #IT-11)

ATS Receives $900,000 in NIH Funding - continued on page 2

ATS Receives $900,000 in NIH Funding - continued from page 1

Surfing to Help Spinal Cord Injuries

• Martin JL, Sloviter RS (2001) Focal Inhibitory Interneuron Loss and Principal Cell Hyperexcitability in the Rat Hippocampus After Microinjection of a Neurotoxic Conjugate of Saporin and a Peptidase-Resistant Analog of Substance P. Journal Comp Neurol 436:127-152. (SSP-SAP, Cat. #IT-11, see cover story)
• Motooka Y, Kondoh T, Nomura T, Tamaki N, Tozaki H, Kanno T, Nishizaki T (2001) Selective Cholinergic Denervation Inhibits Expression of Long-Term Potentiation in the Adult but not Infant Rat Hippocampus. Devel Brain Res 129:119-123. (192-IgG-SAP, Cat. #IT-01)
• Gerashchenko D, Salin-Pascual R, Shiromani PJ (2000) Effects of Hypocretin-Saporin Injections into the Medial Septum on Sleep and Hippocampal Theta. Brain Res 913:106-115. (Orexin-SAP, Cat. #IT-20)
• Daniels D, Miselis RR, Flanagan-Cato LM (2001) Transneuronal Tracing from Sympathectomized Lumbar Epaxial Muscle in Female Rats. J Neurobiol 48(4):278-290. (Anti-DBH-SAP, Cat. #IT-03)
• Harrell LE, Parsons D, Kolasa K (2001) Hippocampal Sympathetic Ingrowth Occurs Following 192-IgG-Saporin Administration. Brain Res 911:158-162. (192-IgG-SAP, Cat. #IT-01)
• Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O (2001) Selective Antibody-Induced Cholinergic Cell and Synapse Loss Produce Sustained Hippocampal and Cortical Hypometabolism with Correlated Cognitive Deficits. Exp Neurol 170:36-47. (192-IgG-SAP, Cat. #IT-01)

• Linster C, Garcia PA, Hasselmo ME, Baxter MG (2001) Selective Loss of Cholinergic Neurons Projecting to the Olfactory System Increases Perceptual Generalization Between Similar, but Not Dissimilar, Odorants. Behav Neurosci 115(4):826-833. (192-IgG-SAP, Cat. #IT-01)
• de Rosa E, Hasselmo ME, Baxter MG (2001) Contribution of the Cholinergic Basal Forebrain to Proactive Interference from Stored Odor Memories During Associative Learning in Rats. Behav Neurosci 115(2):314-327. (192-IgG-SAP, Cat. #IT-01)
• Deuchars J, Deuchars S (2001) It's enough to raise your blood pressure! Trends Neurosci 24(4):200. (Anti-DBH-SAP, Cat. #IT-03)
• Baxter MG  (2001) Effects of selective immunotoxic lesions on learning and memory. Methods Mol Biol 166:249-265. (192-IgG-SAP, Cat. #IT-01)
• Ferreira G, Meurisse M, Tillet Y, Lévy F (2001) Distribution and Co-Localization of Choline Acetyltransferase and p75 Neurotrophin Receptors in the Sheep Basal Forebrain: Implications for the Use of a Specific Cholinergic Immunotoxin. Neurosci 104(2):419-439. (Antibody to NGFR ME20.4, Cat. #AB-N07 and ME20.4-SAP, Cat. #IT-15)
• Gerashchenko D, Kohls MD, Greco M, Waleh NS, Salin-Pascual R, Kilduff TS, Lappi DA, Shiromani PJ (2001) Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat. J Neurosci 21(18):7273-7283. (Orexin-SAP, Cat. #IT-20)

• How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days?
• Will this time course be the same regardless of the targeted toxin used or the method of administration?
• What are some assays/methods to use to be able to graphically demonstrate cell death?

Immunolesioning Hippocampal Inhibitory Interneurons - continued from page 1

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

• Orexin-SAP, Cat. #IT-20

Featured Antibodies:

• Corticotropin Releasing Hormone (CRH/CRF), Cat. #AB-02
• Growth Hormone Releasing Factor (GHRH/GHRF), Cat #AB-01, Cat. #AB-16

Targeting Teaser (Jumble)