HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP (Cat. #IT-03) Lesion Does Not - continued on page 2

SP-SAP (Cat. #IT-07) Licensed to Cell Targeting Technologies

Matthew Kohls Welcomes the Diapered Duo

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• Pang KCH, Nocera R, Secor AJ, Yoder RM (2001) GABAergic septohippocampal neurons are not necessary for spatial memory. Hippocampus 11:814-827. (192-IgG-SAP, Cat. #IT-01)
• Ballmaier M, Casamenti F, Zoli M, Pepeu G, Spano P (2001) Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle. Neurosci 108(2):299-305. (192-IgG-SAP, Cat. #IT-01)
• Wrenn CC, Wiley RG (2001) Lack of effect of moderate Purkinje cell loss on working memory. Neurosci 107(3):433-45. (192-IgG-SAP, Cat. #IT-01 and OX7-SAP, Cat. #IT-02)
• Pain L, Jeltsch H, Lehmann O, Lazarus C, Laalou FZ, Cassel JC (2000) Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Brit J Anaesth 85(6):869-73. (192-IgG-SAP, Cat. #IT-01)
• Butt AE, Bowman TD (2002) Transverse patterning reveals a dissociation of simple and configural association learning abilities in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis. Neurobiol Learn Mem 77:211-233. (192-IgG-SAP, Cat. #IT-01)

• Mattsson A, Ögren SO, Olson L (2002) Facilitation of dopamine-mediated locomotor activity in adult rats following cholinergic denervation. Exp Neurol 174:96-108. (192-IgG-SAP, Cat. #IT-01)
• Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M (2002) Isoflurane and nociception: Spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiol 96:367-74. (Anti-DBH-SAP, Cat. #IT-03)
• Vulchanova L, Olson TH, Stone LS, Riedl MS, Elde R, Honda CN (2001) Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neurosci 108(1):143-55. (IB4-SAP, Cat. #IT-10)
• Power AE, Thal LJ, McGaugh JL (2002) Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala. PNAS 99(4):2315-2319. (192-IgG-SAP, Cat. #IT-01)
• Cahill JFX, Baxter MG (2001) Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning. Eur J Neurosci 14:1856-1864. (192-IgG-SAP, Cat. #IT-01)

• Your recent issue of Targeting Trends stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned.
• Are there any studies which indicate what doses of saporin (by itself or compounded with an antibody) would be hazardous if ingested or injected (i.e. systemic dose level resulting in death or organ dysfunction).

HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP (Cat. #IT-03) Lesion Does Not - continued from page 2

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

• OX7-SAP, Cat. #IT-02

Featured Antibody

• Antibody to OX7 (anti-Thy 1.1), Cat. #AB-N08

Targeting Teaser (Jumble)