Saporin Immunotoxins for Treating Human Hematological Malignancies
(continued on page 2)

Contributed by David J Flavell, PhD, The Simon Flavell Leukaemia Research Unit, Division of Cancer Sciences,
University of Southampton Medical School, United Kingdom.

www.leukaemiabusters.org.uk

Saporin Immunotoxins for Treating Human Hematological Malignancies (continued from page 1, continued on page 6)

• Butt AE, Noble MM, Rogers JL, Rea TE (2002) Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-Saporin lesions of the nucleus basalis magnocellularis. Behav Neurosci 116(2):241-255. (192-IgG-SAP, Cat. #IT-01)
• Bitner RS, Nikkel AL (2002) Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat. Brain Res 938:45-54. (Anti-DBH-SAP, Cat. #IT-03)
• Wang H, Germanson TP, Guyenet PG (2002) Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. J Neurosci 22(9): 3755-3764. (SSP-SAP, Cat. #IT-11)
• Burk JA, Herzog CD, Porter MC, Sarter M (2002) Interactions between aging and cortical cholinergic deafferentation on attention. Neurobiol Aging 23: 467-477. (192-IgG-SAP, Cat. #IT-01)

Featured Antibody

• Antibody to Substance P (Cat. #AB-N10)

• McGaughy J, Dalley JW, Morrison CH, Everitt BJ, Robbins TW (2002) Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task. J Neurosci 22(5):1905-1913. (192-IgG-SAP, Cat. #IT-01)
• Birthelmer A, Dommes E, Jeltsch H, Cassel JC, Jackisch R (2002) Septal grafts and evoked acetylcholine release in the rat hippocampus after 192 IgG-saporin lesions. Regen Transplant 13(7):973-976. (192-IgG-SAP, Cat. #IT-01)
• Burgess SE, Gardell LR, Ossipov MH, Malan Jr TP, Vanderah TW, Lai J, Porreca F (2002) Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22(12):5129-5136. (Dermorphin-SAP, Cat. #IT-12)

Featured Antibody

• Antibody to VAChT (Cat. #AB-N11)

• What are neuropeptide-toxins and how do they work?
• Are neuropeptide-toxins effective suicide transport agents?

Saporin Immunotoxins for Treating Human Hematological Malignancies (continued from page 2)

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

• Anti-Tac (Cat. #AB-18)
• Anti-Tac-SAP (Cat. #IT-24)

Targeting Teaser (Jumble)