Deep Lumbar Neurons Control Ejaculation
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Contributed by William Truitt, PhD, Department of Cell Biology, Neurobiology, and Anatomy, Neuroscience Graduate Program, University of Cincinnati, College of Medicine, Post Office Box 670521, Cincinnati, OH 45267-0521, USA.

Product information related to cover article: SSP-SAP, Cat. #IT-11

2002 Society for Neuroscience ATS Award Winner

SP-SAP as a Chronic Pain Therapeutic: An Update (article)

Scientists Present Innovative Results Using ATS Products

• Gibbs RB (2002) Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task. Horm Behav 42(3):245-257. (192-IgG-SAP, Cat. #IT-01)
• Hartonian I, Mufson EJ, de Lacalle S (2002) Long-term plastic changes in galanin innervation in the rat basal forebrain. Neuroscience 115(3):787-795. (192-IgG-SAP, Cat. #IT-01)
• Helm KA, Han JS, Gallagher M (2002) Effects of cholinergic lesions produced by infusions of 192 IgG-saporin on glucocorticoid receptor mRNA expression in hippocampus and medial prefrontal cortex of the rat. Neuroscience 115(3):765-774. (192-IgG-SAP, Cat. #IT-01)
• Zeitschel U, Schliebs R, Rossner S, Bigl V, Eschrich K, Bigl M (2002) Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion. J Neurochem 83(2):371-380. (192-IgG-SAP, Cat. #IT-01)
• Ricceri L, Hohmann C, Berger-Sweeney J (2002) Early neonatal 192 IgG saporin induces learning impairments and disrupts cortical morphogenesis in rats. Brain Res 954(2):160-172. (192-IgG-SAP, Cat. #IT-01)
• Vale-Martinez A, Baxter MG, Eichenbaum H (2002) Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in rats. Eur J Neurosci 16(6):983-998. (192-IgG-SAP, Cat. #IT-01)
• Nattie EE, Li A (2002) Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity. J Physiol 544(Pt 2):603-616. (SP-SAP, Cat. #IT-07)
• Tokuno H, Chiken S, Kametani K, Moriizumi T (2002) Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats. Neurosci Lett 332(1):5-8. (Dermorphin-SAP, Cat. #IT-12)

Recent Scientific References

• Risbrough V, Bontempi B, Menzaghi F (2002) Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task. Psychopharmacology 164:71-81. (192-IgG-SAP, Cat. #IT-01)
• Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA (2002) Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci 22(20):9086-9098. (SP-SAP, Cat. #IT-07)
• Hartig W, Varga C, Kacza J, Grosche J, Seeger J, Luiten PG, Brauer K, Harkany T (2002) In vivo labeling of rabbit cholinergic basal forebrain neurons with fluorochromated antibodies. NeuroReport 13(11):1395-1398. (NGFR (p75) Mouse Monoclonal, Cat. #AB-N07)
• Hyde LA, Crnic LS (2002) Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and AlzheimerÕs disease. Brain Res 945:26-30. (192-IgG-SAP, Cat. #IT-01)
• Bechade C, Mallecourt C, Sedel F, Vyas S, Triller A (2002) Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. J Neurosci 22(20):8779-8784. (192-IgG-SAP, Cat. #IT-01)
• Beaule C, Amir S (2002) Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats. Exp Neurol 176(2):377-389. (192-IgG-SAP, Cat. #IT-01)
• Ballmaier M, Casamenti F, Scali C, Mazzoncini R, Zoli M, Pepeu G, Spano PF (2002) Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis. Neuroscience 114(1):91-98. (192-IgG-SAP, Cat. #IT-01)
• Pizzo DP, Thal LJ, Winkler J (2002) Mnemonic deficits in animals depend upon the degree of cholinergic deficit and task complexity. Exp Neurol 177:292-305. (192-IgG-SAP, Cat. #IT-01)

Targeting Talk: Custom Conjugations

Part II: Targeted Toxins (Peptide-Saporin conjugates)

• How do I know my peptide will work as a targeted toxin?
• How much peptide do I need to provide for a custom conjugation?
• How much of the saporin conjugate will that give me?
• What is the ratio of saporin to antibody?
• What quality control is involved?
• What is the cost of a custom targeted toxin preparation? How long will it take to complete?
  

Deep Lumbar Neurons Control Ejaculation
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Targeting Teaser Winners from last issue

• Dermorphin-SAP (Cat. #IT-12)
• Fluorescent Conjugates (Cat. #FL-01, FL-02, FL-03)

Targeting Teaser (Jumble)