Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task.
(continued on page 6)

Contributed by ATS’s 2003 Society for Neuroscience Poster of the Year Award Winner: Dr. Jill McGaughy, Boston University, 64 Cummington St., Boston, MA 02215
(see companion story on page 2)

Product information related to cover article: 192-IgG-SAP (Cat. #IT-01)

ATS Gets New Facility for SP-SAP Production (article)

Accomplished Scientist. . . Talented Artist - Rosalind Ridley

Duomo in Prato (watercolor)

Targeting Teaser Winners

ATS’s 2003 SfN Poster Award (see winning abstract)

• Scattoni ML, Calamandrei G, Ricceri L (2003) Neonatal cholinergic lesions and development of exploration upon administration of the GABAa receptor agonist muscimol in preweaning rats. Pharmacol Biochem Behav 76(2):213-221. (192-IgG-SAP, Cat. #IT-01)
• I'Anson H, Sundling LA, Roland SM, Ritter S (2003) Immunotoxic destruction of distinct catecholaminergic neuron populations disrupts the reproductive response to glucoprivation in female rats. Endocrinology 144(10):4325-4331. (Anti-DBH-SAP, Cat. #IT-03)
• Bizon JL, Han JS, Hudon C, Gallagher M (2003) Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze. Hippocampus 13(6):676-684. (192-IgG-SAP, Cat. #IT-01)
• Gadd CA, Murtra P, De Felipe C, Hunt SP (2003) Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse. J Neurosci 23(23):8271-8280. (SP-SAP, Cat. #IT-07)
• Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F (2003) Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. J Neurosci 23(23):8370-8379. (Dermorphin-SAP, Cat. #IT-12)
• Tomaszewicz M, Rossner S, Schliebs R, Cwikowska J, Szutowicz A (2003) Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin. J Neurochem 87(2):318-324. (192-IgG-SAP, Cat. #IT-01)
• Madden CJ, Sved AF (2003) Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol Neurobiol 23(4-5):739-749. (Anti-DBH-SAP, Cat. #IT-03)
• Wiley RG, Harrison MB, Levey A, Lappi DA (2003) Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter. Cell Mol Neurobiol 23:839-850. (Anti-DAT-SAP, Cat. #IT-25)

Recent Scientific References

• Leung LS, Shen B, Rajakumar N, Ma J (2003) Cholinergic activity enhances hippocampal long-term potentiation in CA1 during walking in rats. J Neurosci 23(28):9297-9304. (192-IgG-SAP, Cat. #IT-01)
• Dommergues MA, Plaisant F, Verney C, Gressens P (2003) Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience 121(3):619-628. (Mac-1-SAP, Cat. #IT-06)
• Rinaman L (2003) Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J Neurosci 23(31):10084-10092. (Anti-DBH-SAP, Cat. #IT-03)
• Harmon KM, Wellman CL (2003) Differential effects of cholinergic lesions on dendritic spines in frontal cortex of young adult and aging rats. Brain Res 992:60-68. (192-IgG-SAP, Cat. #IT-01)
• Farhadi HF, Lepage P, Forghani R, Friedman HC, Orfali W, Jasmin L, Miller W, Hudson TJ, Peterson AC (2003) A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J Neurosci 23(32):10214-10223. (CTB-SAP, Cat. #IT-14)
• Birthelmer A, Lazaris A, Riegert C, Marques Pereira P, Koenig J, Jeltsch H, Jackisch R, Cassel JC (2003) Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75NTR receptors? A study using 192 IgG-saporin lesions in rats. Neuroscience 122(4):1059-1071. (192-IgG-SAP, Cat. #IT-01)
• Chiken S, Hatanaka N, Tokuno H (2003) Cytochrome oxidase activity in the monkey globus pallidus and subthalamic nucleus after ablation of striatal interneurons expressing substance P receptors. Neurosci Lett 353(2):103-106. (SP-SAP, Cat. #IT-07)
• Kanai T, Uraushihara K, Okazawa A, Hibi T, Watanabe M (2003) Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Curr Drug Targets Inflamm Allergy 2(2):131-136. (Mac-1-SAP, Cat. #IT-06)

Targeting Talk: Not the Right Stuff

• Are all lots of 192-Saporin (192-IgG-SAP) the same?
• How do I find out the optimal dosage?
• What happens if I use too much immunotoxin

Cholinergic Deafferentation of the Entorhinal Cortex
(continued from page 1)

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