Effects of IB4-SAP on Bladder Overactivity (continued on page 6)

Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213. Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004.

Product information related to cover article: IB4-SAP (Cat. #IT-10)

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• Works SJ, Wilson RE, Wellman CL (2004) Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex. Neurobiol Aging 25(7):963-974. (192-IgG-SAP, Cat. #IT-01)
• Gil-Bea FJ, Dominguez J, Garcia-Alloza M, Marcos B, Lasheras B, Ramirez MJ (2004) Facilitation of cholinergic transmission by combined treatment of ondansetron with flumazenil after cortical cholinergic deafferentation. Neuropharmacology 47(2):225-232. (192-IgG-SAP, Cat. #IT-01)
• Hudson B, Ritter S (2004) Hindbrain catecholamine neurons mediate consummatory responses to glucoprivation. Physiol Behav 82(2-3):241-250. (Anti-DBH-SAP, Cat. #IT-03)
• Mattsson A, Pernold K, Ogren SO, Olson L (2004) Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. Neuroscience 127(3):579-591. (192-IgG-SAP, Cat. #IT-01; OX7-SAP, Cat. #IT-02)
• Kudoh M, Seki K, Shibuki K (2004) Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex. Neurosci Res 50(1):113-123. (192-IgG-SAP, Cat. #IT-01)
• Helm KA, Ziegler DR, Gallagher M (2004) Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions. Hippocampus 14(5):628-635. (192-IgG-SAP, Cat. #IT-01)

Recent Scientific References

• Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC (2004) Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci 19(12):3305-3316. (mu p75-SAP, Cat. #IT-16)
• Wang G, Anrather J, Huang J, Speth RC, Pickel VM, Iadecola C (2004) NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci 24(24):5516-5524. (Anti-Ang II, Cat. #AB-N27AP)
• Cooper-Kuhn CM, Winkler J, Kuhn HG (2004) Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. J Neurosci Res 77(2):155-165. (192-IgG-SAP, Cat. #IT-01)
• Ricceri L, Minghetti L, Moles A, Popoli P, Confaloni A, De Simone R, Piscopo P, Scattoni ML, di Luca M, Calamandrei G (2004) Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Exp Neurol 189(1):162-172. (192-IgG-SAP, Cat. #IT-01)
• Winters BD, Dunnett SB (2004) Selective lesioning of the cholinergic septo-hippocampal pathway does not disrupt spatial short-term memory: a comparison with the effects of fimbria-fornix lesions. Behav Neurosci 118(3):546-562. (192-IgG-SAP, Cat. #IT-01)
• Lalonde R, Strazielle C (2003) The effects of cerebellar damage on maze learning in animals. Cerebellum 2(4):300-309. (OX7-SAP, Cat. #IT-02)

Targeting Talk: Effective Toxins

• Why do your directions for SSP-SAP state that it is to be used within hours after dissolution? To my knowledge, both proteins and peptides are stable in clean solution.
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Effects of IB4-SAP on Bladder Overactivity (continued from page 1)

Upcoming Events

• Society for Neuroscience; October 23-27, 2004; San Diego, CA; Booth 3117
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The Society for Neuroscience meeting comes to San Diego October 23-27

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