IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers (continued on page 6)

Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner: Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540.

Product information related to cover article: IB4-SAP (Cat. #IT-10)

ATS Seeks Strategic Partner for Chronic Pain Drug (article)

Happy New Year from ATS!

Michelle Pearson wins 2004 SfN Poster Award

Recent Scientific References

• Jeltsch H, Lazarus C, Cosquer B, Galani R, Cassel JC (2004) No facilitation of amphetamine- or cocaine-induced hyperactivity in adult rats after various 192 IgG-saporin lesions in the basal forebrain. Brain Res 1029(2): 259-271. (192-IgG-SAP, Cat. #IT-01)
• Tarpley JW, Kohler MG, Martin WJ (2004) The behavioral and neuroanatomical effects of IB(4)-saporin treatment in rat models of nociceptive and neuropathic pain. Brain Res 1029(1):65-76. (IB4-SAP, Cat. #IT-10)
• Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA (2004) Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. J Neurophysiol [epub] Sep 29. (SP-SAP, Cat. #IT-07)
• Cameron NM, Carey P, Erskine MS (2004) Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy. Brain Res 1022(1-2):137-147. (Anti-DBH-SAP, Cat. #IT-03)
• Ma J, Shen B, Rajakumar N, Leung LS (2004) The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine. Behav Brain Res 155(1):153-166. (192-IgG-SAP, Cat. #IT-01)
• Hodges MR, Opansky C, Qian B, Davis S, Bonis J, Bastasic J, Leekley T, Pan LG, Forster HV (2004) Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe-area in awake goats. J Appl Physiol 97(6):2236-2247. (SP-SAP, Cat. #IT-07; Saporin, Cat. #PR-01)

Recent Scientific References

• Fargo KN, Sengelaub DR (2004) Exogenous testosterone prevents motoneuron atrophy induced by contralateral motoneuron depletion. J Neurobiol 60(3):348-359. (CTB-SAP, Cat. #IT-14)
• Estacio MA, Tsukamura H, Reyes BA, Uenoyama Y, I'anson H, Maeda K (2004) Involvement of brainstem catecholaminergic inputs to the hypothalamic paraventricular nucleus in estrogen receptor alpha expression in this nucleus during different stress conditions in female rats. Endocrinology 145(11):4917-4926. (Anti-DBH-SAP, Cat. #IT-03)
• Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah T, Davis S, Forster HV (2004) Small reduction of neurokinin-1 receptor-expressing neurons in the pre-Botzinger complex area induces abnormal breathing periods in awake goats. J Appl Physiol 97(5):1620-1628. (SP-SAP, Cat. #IT-07)
• Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah TR, Davis S, Forster HV (2004) Large lesions in the pre-Botzinger complex area eliminate eupneic respiratory rhythm in awake goats. J Appl Physiol 97(5):1629-1636. (SP-SAP, Cat. #IT-07)
• Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S (2004) Basomedial hypothalamic injections of neuropeptide Y-saporin (NPY-SAP) selectively disrupt hypothalamic controls of food intake. Endocrinology [epub] Dec 16. (NPY-SAP, Cat. #IT-28)

Targeting Talk: Effective Toxins

• In the most recent issue (Oct-Nov-Dec 2004), you addressed the question of one molecule of saporin killing a cell. Your response overlooked the data on ricin, abrin and modeccin.
• Also, if the data on ricin-induced apoptosis is correct (numerous authors), and I believe it is, then at low doses, the cells die from triggering apoptosis which seem possible with a single molecule of RIP free in the cytoplasm.

Upcoming Events

• Experimental Biology, San Diego CA: April 2-6, Booth 716
• American Assoc for Cancer Research, Anaheim CA: April 17-20, Booth 371

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IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers (continued from page 1)

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