The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin (continued on page 6)

Josephine Lai, Wenjun Zhang, Hamid Badghisi, Victor J. Hruby and Frank Porreca,
Departments of Pharmacology and Chemistry, The University of Arizona, Tucson, AZ 85724.

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Recent Scientific References

• Yamazaki Y, Jia Y, Hamaue N, Sumikawa K (2005) Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction. Eur J Neurosci 22(4):845-860. (Cat. #IT-01)
• Vago R, Marsden CJ, Lord JM, Ippoliti R, Flavell DJ, Flavell SU, Ceriotti A, Fabbrini MS (2005) Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells. FEBS J 272(19):4983-4995. (Cat. #PR-01)
• Sherren N, Pappas BA (2005) Selective acetylcholine and dopamine lesions in neonatal rats produce distinct patterns of cortical dendritic atrophy in adulthood. Neuroscience 136(2):445-456. (Cat. #IT-01)
• Saenz C, Dominguez R, de Lacalle S (2006) Estrogen contributes to structural recovery after a lesion. Neurosci Lett 392(3):198-201. (Cat. #IT-01)
• McKay LC, Janczewski WA, Feldman JL (2005) Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nat Neurosci 8(9):1142-1144. (Cat. #IT-07)

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• Mattsson A, Lindqvist E, Ogren SO, Olson L (2005) Increased phencyclidine-induced hyperactivity following cortical cholinergic denervation. Neuroreport 16(16):1815-1819. (Cat. #IT-01)
• Hawkes C, Jhamandas JH, Kar S (2005) Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta. J Neurochem 95(1):263-272. (Cat. #IT-01)
• Gerashchenko D, Blanco-Centurion CA, Miller JD, Shiromani PJ (2006) Insomnia following hypocretin2-saporin lesions of the substantia nigra. Neuroscience 137(1):29-36. (Cat. #IT-20)
• Frielingsdorf H, Thal LJ, Pizzo DP (2005) The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behav Brain Res [epub Dec 2]. (Cat. #IT-01)
• Fontan-Lozano A, Troncoso J, Munera A, Carrion AM, Delgado-Garcia JM (2005) Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning. Learn Mem 12(6):557-563. (Cat. #IT-01)

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• In a recent experiment using a saporin-antibody conjugate injected systemically we saw changes in dendritic cells that could be consistent with an LPS effect. Does ATS test for LPS and has this ever been identified as a problem before?

This brilliant artistic expression is a creationby Dr. Roger Guillemin (see brief bio on page 2). The title of this piece is Hamadryad.

The Biologically Active Cholecystokinin (26-33) peptide,[Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin
(continued from page 1)

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