Targeted Toxins in Pain (continued on page 6)

Summary of contribution to "Recontres en toxinologie, 2005" by Ronald G. Wiley, Neurology Service (127) - VA TVHS, 1310 24th Avenue, South, Nashville, TN 37212

Product information related to cover article: 192-IgG-SAP (Cat. #IT-01), Anti-DBH-SAP (Cat. #IT-03), Anti-SERT-SAP (Cat. #IT-23), OX7-SAP (Cat. #IT-02), SSP-SAP (Cat. #IT-11), Dermorphin-SAP (Cat. #IT-12)

Chronic Pain Drug - Update on SP-SAP Development (article)

Targeting Teaser Winners

Recent Scientific References

• Easton A, Dwyer E, Pfaff DW (2006) Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Behav Neurosci 120(1):1-9. (Cat. #IT-20)
• Foehr ED, Lorente G, Kuo J, Ram R, Nikolich K, Urfer R (2006) Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Cancer Res 66(4):2271-2278. (Cat. #IT-18; Cat. #IT-25; Cat. #IT-04)
• Weyergang A, Selbo PK, Berg K (2006) Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin. J Control Release 111(1-2):165-173. (Cat. #IT-27)
• Emgard M, Paradisi M, Pirondi S, Fernandez M, Giardino L, Calza L (2006) Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Neurobiol Aging [Epub Jan 4]. (Cat. #IT-01; Cat. #PR-01)
• Li A, Nattie E (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol 570(Pt 2):385-396. (Cat. #IT-03; Cat. #IT-18)

Recent Scientific References

• Garrett JE, Kim I, Wilson RE, Wellman CL (2006) Effect of N-METHYL-d-aspartate receptor blockade on plasticity of frontal cortex after cholinergic deafferentation in rat. Neuroscience [Epub Mar 7]. (Cat. #IT-01)
• Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL (2006) Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91(1):286-298. (Cat. #IT-07)

Upcoming Events

Abstracts from the Experimental Biology Meeting, April 1-4, San Francisco, CA

• Effect of lesions in the nucleus tractus solitarius on hypercapnic ventilatory response in awake rats. Wilkinson KA, Fu Z, Powell FL. Abstract #480.9
• Central baroreflex interruption, cardiac toxicity, and sudden death. Nayate AP, Moore SA, Weiss RM, Lin L-H, Talman WT. Abstract #467.19
• Brainstem catecholaminergic neurons affect mean arterial pressure and heart rate at rest and during hypercapnic stress in conscious rats. Emond LA, Li A, Nattie E. Abstract #229.38

Targeting Talk: Retrograde Transport

• I spoke with someone from your technical service over the phone and got the impression that your product dermorphin-SAP (Cat. #IT-12) is not a retrograde and will only affect the terminals or the cells that express mu opioid receptors in the injection site in the brain. I have three questions: 1) Do you have any written document on this issue? 2) Will dermorphin-SAP also kill terminals in the injection site or just cell bodies? And 3) If it also kills terminals, will it affect their remote cell bodies?
• Can I inject NPY-SAP to destroy projections through retrograde transport?

Targeted Toxins in Pain (continued from page 1)

Targeting Tools: Featured Products

• Fluorescent Conjugates (Catalog)
• Flow Cytometry Service (www.CytometryRes.com)

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