Safety and Efficacy of Substance P-SAP (continued on page 6)

by Jeffrey W. Allen, Ph.D.
The author is currently a Senior Scientist in Emerging Therapies at Medtronic Neurological located in Minneapolis, MN. There is no association, financial or otherwise, between Medtronic, Inc. and Advanced Targeting Systems.

Product information related to cover article: SP-SAP (Cat. #IT-07)

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Recent Scientific References

• Dinh TT, Flynn FW, Ritter S (2006) Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus. Am J Physiol Regul Integr Comp Physiol [Epub May 4]. (Cat. #IT-03)
• Fitz NF, Gibbs RB, Johnson DA (2006) Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections. Brain Res Bull 69(6):660-665. (Cat. #IT-01)
• Basbaum AI, Julius D (2006) Toward better pain control. Sci Am 294(6):60-67. (Cat. #IT-07)
• Li AJ, Wang Q, Ritter S (2006) Differential responsiveness of dopamine-beta-hydroxylase gene expression to glucoprivation in different catecholamine cell groups. Endocrinology 147(7):3428-3434. (Cat. #IT-03)
• Madden CJ, Stocker SD, Sved AF (2006) Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla (RVLM) neurons. Am J Physiol Regul Integr Comp Physiol [Epub Apr 20]. (Cat. #IT-03)

Recent Scientific References

• Knox D, Berntson GG (2006) Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. Behav Neurosci 120(2):307-312. (Cat. #IT-01)
• Saurer TB, Carrigan KA, Ijames SG, Lysle DT (2006) Suppression of natural killer cell activity by morphine is mediated by the nucleus accumbens shell. J Neuroimmunol 173(1-2):3-11. (Cat. #IT-25)
• Nguyen DH, Ball ED, Varki A (2006) Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs. Exp Hematol 34(6):728-735. (Cat. #IT-04)
• Vera-Portocarrero LP, Yie JX, Kowal J, Ossipov MH, King T, Porreca F (2006) Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 130(7):2155-164. (Cat. #IT-12)
• Traissard N, Herbeaux K, Cosquer B, Jeltsch H, Ferry B, Galani R, Pernon A, Majchrzak M, Cassel JC (2006) Combined damage to entorhinal cortex and cholinergic basal forebrain neurons, two early neurodegenerative features accompanying Alzheimer's Disease: Effects on locomotor activity and memory functions in rats. Neuropsychopharmacology [Epub Jun 7]. (Cat. #IT-01; Cat. #IT-02)

Targeting Talk: Retrograde Transport

• I have a question about the issues raised in the last edition of Targeting Trends (Volume 7, Issue 2). There is a comment "In fact, we recommend that you wait two weeks at least to see immunohistological evidence of a toxic effect after injection of a saporin toxin in vivo." Are there data to support this recommendation?
  As a researcher who utilizes your toxin products I often get asked about the time course of toxin action. It's difficult to answer because the literature is currently limited with regard to in vivo toxin application. Any citations, advice, or comments would be greatly appreciated.
• Do you have a product which can be used to produce retrograde lesions WITHOUT killing cells at the site of injection? What I'd like to do is to kill neurons that project to an efferent nucleus without damaging neurons in the efferent nucleus itself.

Safety and Efficacy of Substance P-SAP (continued from page 1)

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