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Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain
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Neelima Chauhan, Dept Anesthes/Anat & Cell Bio, Univ Illinois-Chicago; J. Brown VA Med Ctr Chicago, Chicago, IL and winner of the 2006 SfN Poster Award for work using ATS products.
Product information related to cover article: mu p75-SAP (Cat. #IT-16)
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Targeting Teaser Winners
Surf Contest
Upcoming Events
- Spring Brain Conference, Sedona AZ — March 14-17, 2007
- American Association for Cancer Research, Los Angeles CA — April 14-18, 2007
2006 SfN Poster Award Winner (see winning
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Recent Scientific References
- Lu J, Sherman D, Devor M, Saper CB (2006) A putative flip-flop switch for control of REM sleep. Nature 441(1):589-594. (Cat. #IT-20)
- Turner LH, Lim CE, Heinrichs SC (2006) Antisocial and seizure susceptibility phenotypes in an animal model of epilepsy are normalized by impairment of brain corticotropin-releasing factor. Epilepsy Behav [Epub Oct 3]. (Cat. #IT-13)
- Blanco-Centurion CA, Shiromani A, Winston E, Shiromani PJ (2006) Effects of hypocretin-1 in 192-IgG-saporin-lesioned rats. Eur J Neurosci 24(7):2084-2088. (Cat. #IT-01)
- Abdala AP, Schoorlemmer GH, Colombari E (2006) Ablation of NK(1) receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats. Brain Res 1119(1):165-173. (Cat. #IT-07; Cat. #PR-01)
- Milstein JA, Lehmann O, Theobald DE, Dalley JW, Robbins TW (2007) Selective depletion of cortical noradrenalin by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat. Psychopharmacology (Berl) 190(1):51-63. (Cat. #IT-03)
- Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F (2006) Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain [Epub Nov 21]. (Cat. #IT-07; Cat. #PR-01)
- Ma W, Eisenach JC (2007) Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation. Brain Res 1127(1):52-58. (Cat. #IT-01)
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Recent Scientific References
- Banihashemi L, Rinaman L (2006) Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine. J Neurosci 26(44):11442-11453. (Cat. #IT-03)
- Marcos B, Gil-Bea FJ, Hirst WD, Garcia-Alloza M, Ramirez MJ (2006) Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Eur J Neurosci 24(5):1299-1306. (Cat. #IT-01)
- van der Staay FJ, Bouger P, Lehmann O, Lazarus C, Cosquer B, Koenig J, Stump V, Cassel JC (2006) Long-term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone-field task and noncognitive measures in rats. Hippocampus 16(12):1061-1079. (Cat. #IT-01)
- Walker BR, Diefenbach KS, Parikh TN (2007) Inhibition within the nucleus tractus solitarius (NTS) ameliorates environmental exploration deficits due to cerebellum lesions in an animal model for autism. Behav Brain Res 176(1):109-120. (Cat. #IT-01; Cat. #IT-02)
- Hawkes C, Kabogo D, Amritraj A, Kar S (2006) Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain. Am J Pathol 169(4):1140-1154. (Cat. #IT-01)
- Willis CL, Ray DE, Marshall H, Elliot G, Evans JG, Kind CN (2006) Basal forebrain cholinergic lesions reduce heat shock protein 72 response but not pathology induced by the NMDA antagonist MK-801 in the rat cingulate cortex. Neurosci Lett 407(2):112-117. (Cat. #IT-01)
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Targeting Talk: Targeted Toxin Controls
- Your targeted toxin kits come with different controls. I'm not sure of the best way to use them. For example, with the anti-SERT-SAP (Cat. #IT-23) kit there is included unconjugated antibody, unconjugated saporin, and a control conjugate, mouse IgG-SAP. Should I use them all in the same experiment or for different purposes?
- What about for the peptide toxins like orexin-SAP (Cat. #IT-20) or SP-SAP (Cat. #IT-07) — what controls are available for those?
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Cholinergic Immunolesioning Produced Tangle-like Inclusions
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Recent Scientific References
- Scattoni ML, Adriani W, Calamandrei G, Laviola G, Ricceri L (2006) Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats. Behav Pharmacol 17(5-6):517-524. (Cat. #IT-01)
- Keener WK, Rivera VR, Young CC, Poli MA (2006) An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence. Anal Biochem 357(2):200-207. (Cat. #PR-01)
- Furlong T, Carrive P (2006) Neurotoxic lesions centered on the perifornical hypothalamus abolish the cardiovascular and behavioral responses of conditioned fear to context but not of restraint. Brain Res 1128(1):107-119. (Cat. #IT-20; Cat. #IT-21)
- Pedrino GR, Maurino I, de Almeida Colombari DS, Cravo SL (2006) Role of catecholaminergic neurons of the caudal ventrolateral medulla in cardiovascular responses induced by acute changes in circulating volume in rats. Exp. Physiol 91(6):995-1005. (Cat. #IT-03)
- Garcia-Alloza M, Zaldua N, Diez-Ariza M, Marcos B, Lasheras B, Javier Gil-Bea F, Ramirez MJ (2006) Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol 65(11):1074-1081. (Cat. #IT-01)
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Targeting Tools
Gangsta Gallery |
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Targeting Technology Tutorial
Targeting Teaser (Jumble)
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