Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways. (continued on page 6)

Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211

Product information related to cover article: SP-SAP (Cat. #IT-07)

SP-SAP Drug Development Update (see text)

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• American Assoc for Cancer Research, Los Angeles CA, Booth #1553 — April 14-18, 2007
• Experimental Biology, Washington DC, Booth #215— April 28-May 2, 2007

New Targets: Insula Receptors

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Recent Scientific References

• Alenda A, Nunez A (2007) Cholinergic modulation of sensory interference in rat primary somatosensory cortical neurons. Brain Res 1133:158-167. (Cat. #IT-01)
• Ohtori S, Inoue G, Koshi T, Ito T, Doya H, Moriya H, Takahashi K (2006) Substance P-saporin down-regulates substance P receptor immunoreactive sensory dorsal root ganglion neurons innervating the lumbar intervertebral discs in rats. Spine 31:2987-2991. (Cat. #IT-07)
• Cabrera SM, Chavez CM, Corley SR, Kitto MR, Butt AE (2006) Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Behav Neurosci 120:298-306. (Cat. #IT-01)
• Aztiria E, Capodieci G, Arancio L, Leanza G (2007) Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Neurosci Lett 416(2):133-137. (Cat. #IT-01)
• Elson-Schwab L, Garner OB, Schuksz M, Esko JD, Tor Y (2007) Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. J Biol Chem [Epub Feb 20]. (Cat. #IT-27)
• Potts JT, Fong AY, Anguelov PI, Lee S, McGovern D, Grias I (2007) Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex. Neuroscience 145(3):1168-1181. (Cat. #IT-07)
• Fletcher BR, Baxter MG, Guzowski JF, Shapiro ML, Rapp PR (2007) Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory. Hippocampus 17:227-234. (Cat. #IT-01)

Recent Scientific References

• Truitt WA, Sajdyk TJ, Dietrich AD, Oberlin B, McDougle CJ, Shekhar A (2007) From anxiety to autism: spectrum of abnormal social behaviors modeled by progressive disruption of inhibitory neuronal function in the basolateral amygdala in Wistar rats. Psychopharmacology (Berl) [Epub Feb3]. (Cat. #IT-21; Cat. #IT-11)
• Martinez L, de Lacalle S (2007) Astrocytic reaction to a lesion, under hormonal deprivation. Neurosci Lett 415(2):190-193. (Cat. #IT-01)
• Yip WL, Weyergang A, Berg K, Tonnesen HH, Selbo PK (2007) Targeted Delivery and Enhanced Cytotoxicity of Cetuximab-Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells. Mol Pharm 4(2):241-251. (Cat. #IT-27)
• Bailey AM, Lee JM (2007) Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set. Brain Res 1136:110-121. (Cat. #IT-01)
• Dwyer TA, Servatius RJ, Pang KC (2007) Noncholinergic lesions of the medial septum impair sequential learning of different spatial locations. J Neurosci 27:299-303. (Cat. #IT-01)
• Zhao P, Waxman SG, Hains BC (2007) Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci 27:2357-2368. (Cat. #IT-06)
• Quinlivan M, Chalon S, Vergote J, Henderson J, Katsifis A, Kassiou M, Guilloteau D (2007) Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neurosci Lett 415(2):97-101. (Cat. #IT-01)

Targeting Talk: Agonist Effects

• Do conjugated toxins (dermorphin-saporin in particular) exhibit agonist effects? I've generated behavioral and tissue time course effects but have not established agonist effects for this conjugated toxin.

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SP-SAP Selectively Disrupts Baroflex-dependent Pathways (continued from page 1)

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