Targeting Trends
Oct-Nov-Dec 2007

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Newsletter Highlights

Page 1
PDF: 484KB

Inducing Central Sensitization with a Substance P/ Cholera Toxin Conjugate
(continued on page 6)

Contributed by Robert M. Caudle, Ph.D.
University of Florida College of Dentistry, Gainesville, FL 32610

Product information related to cover article: SP-CTA (Cat. #IT-39)

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PDF: 360 KB

Summer Fun

Flow Cytometry Services & Specials (www.CytometryRes.com)

Page 3
PDF: 136 KB

Recent Scientific References

  • Mattsson A, Olson L, Svensson TH, Schilstrom B (2007) Cortical cholinergic deficiency enhances amphetamine-induced dopamine release in the accumbens but not in the striatum. Exp Neurol. (Cat. #IT-01)
  • Rinaman L, Dzmura V (2007) Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride. Am J Physiol Regul Integr Comp Physiol. (Cat. #IT-03)
  • Ricceri L, Cutuli D, Venerosi A, Scattoni ML, Calamandrei G (2007) Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats. Behav Brain Res 183:111-117. (Cat. #IT-01)
  • Martin MM, Wallace DG (2007) Selective hippocampal cholinergic deafferentation impairs self-movement cue use during a food hoarding task. Behav Brain Res 183:78-86. (Cat. #IT-01)
  • Chambon C, Paban V, Manrique C, Alescio-Lautier B (2007) Behavioral and immunohistological effects of cholinergic damage in immunolesioned rats: Alteration of c-Fos and polysialylated neural cell adhesion molecule expression. Neuroscience 147:893-905. (Cat. #IT-01)
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PDF: 148 KB

Recent Scientific References

  • Shen FM, Wang J, Ni CR, Yu JG, Wang WZ, Su DF (2007) Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT(2A) receptors. Clin Exp Pharmacol Physiol 34:702-707. (Cat. #IT-23)
  • Gibbs RB (2007) Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections. Horm Behav 52:352-359. (Cat. #IT-01)
  • Percaccio CR, Pruette AL, Mistry ST, Chen YH, Kilgard MP (2007) Sensory experience determines enrichment-induced plasticity in rat auditory cortex. Brain Res 1174:76-91. (Cat. #IT-01)
  • Magrassi L, Grimaldi P, Ibatici A, Corselli M, Ciardelli L, Castello S, Podesta M, Frassoni F, Rossi F (2007) Induction and survival of binucleated Purkinje neurons by selective damage and aging. J Neurosci 27:9885-9892. (Cat. #IT-01)
  • Dias MB, Nucci TB, Margatho LO, Antunes-Rodrigues J, Gargaglioni LH, Branco LG (2007) Raphe Magnus Nucleus is involved in ventilatory but not hypothermic response to CO2. J Appl Physiol. (Cat. #IT-23; Cat. #IT-18)
  • Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ (2007) A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis. (Cat. #IT-06)
Page 5
PDF: 96 KB

Targeting Talk

  • Can you tell me how I would calculate the amount of a SAP-type targeted toxin that I might want to buy based on a desire to bilaterally kill cells of interest within a typical diffusion zone around an injection site in a rodent brain? Use CRF-SAP(Cat. #IT-13) as an example. Are we talking a few hundred dollars to run 40 animals or thousands of dollars?
  • Will one injection permanently and reliably accomplish the deed?
  • What are the typical criticisms (e.g., perhaps related to non-specific effects or interpretive difficulties) that the use of such products engender?

Upcoming Events

  • Society for Neuroscience, San Diego CA, Booth #1022 — November 3-7, 2007
  • American Society for Cell Biology, Washington, DC, Booth 602 — December 1-5, 2007

Targeting Teaser Winners

Page 6
PDF: 200 KB

Inducing Central Sensitization with SP-CTA (continued from page 1)

Page 7
PDF: 252 KB

Targeting Tools: New Products

Gangsta Gallery

Page 8
PDF: 408 KB
Targeting Technology Tutorial

Targeting Teaser (Crossword)

 

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