Targeting Trends
Jan-Feb-Mar 2009

Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers. - read article
(continued on page 6)

Contributed by Paul R. Hess, Adam S. Buntzman, Sabrina L. Murray, Ellen F. Young, and Jeffrey A. Frelinger; North Carolina State University College of Veterinary Medicine, Raleigh, NC; and University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC.

Product information related to cover article: Streptavidin-ZAP (Cat. #IT-27), FITC-labeled SAP antibody (Cat. #FL-02)

Annual Society for Neuroscience Poster Award (see winning abstract)
featuring Anti-DBH-SAP (Cat. #IT-03)

Recent Scientific References - read online

• Nayate A, Moore SA, Weiss RM, Taktakishvili O, Lin LH, Talman WT (2008) Cardiac Damage after Lesions of the Nucleus Tractus Solitarii. Am J Physiol Regul Integr Comp Physiol [Epub Nov 19]. (Cat. #IT-11)
• Rouleau C, Curiel M, Weber W, Smale R, Kurtzberg L, Mascarello J, Berger C, Wallar G, Bagley R, Honma N, Hasegawa K, Ishida I, Kataoka S, Thurberg BL, Mehraein K, Horten B, Miller G, Teicher BA (2008) Endosialin protein expression and therapeutic target potential in human solid tumors: sarcoma versus carcinoma. Clin Cancer Res 14:7223-7236. (Cat. #IT-22; Cat. #IT-18)
• Burk JA, Lowder MW, Altemose KE (2008) Attentional demands for demonstrating deficits following intrabasalis infusions of 192 IgG-saporin. Behav Brain Res 195:231-238. (Cat. #IT-01)
• Martin MM, Winter SS, Cheatwood JL, Carter LA, Jones JL, Weathered SL, Wagner SJ, Wallace DG (2008) Organization of food protection behavior is differentially influenced by 192 IgG-saporin lesions of either the medial septum or the nucleus basalis magnocellularis. Brain Res 1241:122-135. (Cat. #IT-01)
• Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J (2008) Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain [Epub Dec 2]. (Cat. #IT-12; Cat. #IT-31; Cat. #PR-01)

Recent Scientific References - read online

• Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats. Brain Res Bull [Epub Nov 24]. (Cat. #IT-01)
• Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats. Exp Brain Res [Epub Oct 21]. (Cat. #IT-01)
• Fitz NF, Gibbs RB, Johnson DA (2008) Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy. Brain Res Bull 77:356-360. (Cat. #IT-01)
• Bee LA, Dickenson AH (2008) Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin. Pain 140:209-223. (Cat. #IT-12; Cat. #PR-01)
• Kalinchuk AV, McCarley RW, Stenberg D, Porkka-Heiskanen T, Basheer R (2008) The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience 157:238-253. (Cat. #IT-01)
• Goz D, Studholme K, Lappi DA, Rollag MD, Provencio I, Morin LP (2008) Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. PLoS ONE 3:e3153. (Cat. #IT-35, Cat. #IT-44)

Targeting Talk (see text)

• Anti-IgM-ZAP (Anti-M-ZAP, Cat. #IT-30)

Upcoming Events

• Experimental Biology, New Orleans, LA — April 18-22, 2009 — Booth #218
• American Association for Cancer Research, Denver, CO — April 18-22, 2009— Booth #1760

Targeting Teaser Winners

Selective lesions of ITC cells reveal their role in extinction of conditioned fear. - read article
(continued from page 1)

Targeting Tools: Assays from Cytometry Research

• Cancer Cell Lines - Compound Screening
  (see service details)

Gangsta Gallery

Targeting Teaser (Jumble)
Complete and Submit online!