ATS

Advanced Targeting Systems Site Map

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ATS Advanced
Targeting
Systems
10451 Roselle Street, #300
San Diego, CA 92121 USA

Tollfree: (877) 889-2288
Phone: (858) 642-1988
Fax: (858) 642-1989
 

Advanced Targeting Systems (ATS) is a San Diego-based biotechnology company dedicated to providing quality targeting reagents: immunotoxins, targeted toxins, saporin, and antibodies for scientific research and pharmaceutical development. These reagents make it possible for scientists to perform Molecular Neurosurgery lesioning of target cells (in vitro or in vivo) with no destruction of bystander populations.

Advanced Targeting Systems has pioneered the use of targeted toxins. These products include specific lesioning agents for cholinergic basal forebrain neurons, noradrenergic and adrenergic neurons, macrophages and microlia and a pan-neuronal agent that strikes an epitope expressed on all neurons. In addition, Advanced Targeting Systems produces and sells "second immunotoxins" (or "secondary conjugates") which allow users to convert their own targeting antibodies into specific cytotoxic agents. Advanced Targeting Systems also sells neuronal and neuroendocrine antibodies.

Below is a listing of this website.

Home

Targeting Tutorial
illustrations to help you understand the targeting technology

  • Step 1 - Get an antibody specific to your cell type
  • Step 2 - Use a potent toxin, Saporin
  • Step 3 - ATS binds Saporin with your antibody into a powerful targeting agent
  • Step 4 - The Saporin conjugate seeks out target markers
  • Step 5 - The Saporin conjugate is internalized
  • Step 6 - The Saporin conjugate enters the cell
  • Step 7 - The Saporin bond is broken
  • Step 8 - The ribosomes are inactivated, cell death.

Product Catalog
listing of antibodies, targeted toxins, immunotoxins, and proteins available for sale

  • Antibodies and Fluorescent Conjugates
  • Control Conjugates
    • Controls are a vital part of the scientific procedure; without them it is difficult to isolate the specific effects from the non-specific or artifactual. This control molecule is the same molecular weight, consists of similar, comparable materials and is synthesized with the same protocols as the targeted toxins. The difference is the cell-specific targeting agents are replaced with "blanks," antibodies or peptides that have no specificity, and no ability to target cells. In short, they are the perfect control molecules for behavioral experiments with Advanced Targeting Systems' targeted toxins.
  • Targeted Toxins
    • Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery. The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized). The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface. The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death. Cells that do not have the cell surface marker are not affected.
    • Targeted CTA conjugates are powerful and specific stimulatory agents. These conjugates use the catalytic A subunit of cholera toxin (CTA) bound to a targeting agent (anything that is recognized on the cell surface and internalized). The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface. The conjugate is internalized, CTA activates the cAMP pathway within the cells by ribosylating adenylate cyclase. Cells that do not have the cell surface marker are not affected.
  • Proteins, Peptides & Antigens
  • Secondary Conjugates
    • Secondary conjugates are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis). The secondary conjugate uses the secondary antibody to "piggyback" onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Once the conjugate is internalized, saporin breaks away from the targeting agent and inactivates the ribosomes, which causes protein inhibition and, ultimately, cell death. Potency may vary according to the specificity and affinity of YOUR antibody to ITS receptor. Secondary conjugates are most effective in determining specificity of your antibody and suitability for conjugation as a primary immunotoxin.¬†When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.
  • Tag-Targeted Toxins
    • Tag-targeted toxins are powerful and specific lesioning agents used in the technique known as Molecular Surgery. The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent that "piggybacks" onto YOUR protein-tagged cells. Once the conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death. Cells that do not have the cell surface marker are not affected.
    Custom Services
  • New Products
  • Protocols
  • Data Sheets

New Targets
new therapeutic and diagnostic targets

News
press releases, articles, meeting abstracts, and Targeting Trends newsletters

Scientific References
references using products sold by Advanced Targeting Systems

Updates to ATS products and content

Search Advanced Targeting Sytems website

Contact Advanced Targeting Systems