Advanced Targeting Systems' technology - Molecular Neurosurgery -
is a modification of one of the most widely used techniques in the neurosciences:
lesioning of a region by surgical means and observation of the effect.
Watch this multi-media
presentation to understand
how this advanced
targeting system can work for you.
Or follow these simple
illustrations to
understand
how this advanced targeting system can work for you.
- Get an antibody specific to your cell type. Or use anything that binds to a cell surface molecule and is internalized.
- Use a potent cytotoxin. Safe in the lab. Lethal in the cell.
- Advanced Targeting Systems puts them together to make a powerful targeting agent.
- The conjugate seeks out target markers on the cell surface.
- Once attached to its target receptor, the saporin conjugate is internalized. Cells which do not have the target receptor will not be affected.
- The SAPORIN conjugate enters the cell.
- The bond between SAPORIN and the targeting agent is broken in the endosome.
- Saporin inactivates the ribosome resulting in cell death.
